神经节通过烟碱受体的传递对于豚鼠回肠的蠕动反射是否至关重要？

Is ganglionic transmission through nicotinic receptors essential for the peristaltic reflex in the guinea-pig ileum?

作者信息

Barthó L, Holzer P, Lembeck F

机构信息

Department of Pharmacology, University Medical School of Pécs, Hungary.

出版信息

Neuropharmacology. 1987 Nov;26(11):1663-6. doi: 10.1016/0028-3908(87)90018-9.

DOI:10.1016/0028-3908(87)90018-9

PMID:2893310

Abstract

Peristaltic reflex activity in the guinea-pig isolated ileum was elicited by slow intraluminal infusion of Tyrode solution. The reflex was abolished by the ganglionic blocking drug hexamethonium. However, in more than half of the preparations, the peristaltic reflex was restored by the opioid antagonist naloxone. Hexamethonium-resistant peristaltic waves were blocked by tetrodotoxin or atropine. These data suggest that ganglionic transmission through nicotinic acetylcholine receptors may not be essential for the peristaltic reflex provided that the inhibitory action of endogenous opioids has been eliminated.

摘要

通过在豚鼠离体回肠腔内缓慢输注台氏液来引发蠕动反射活动。神经节阻断药物六甲铵可消除该反射。然而，在超过半数的标本中，阿片类拮抗剂纳洛酮可使蠕动反射恢复。河豚毒素或阿托品可阻断六甲铵抵抗性蠕动波。这些数据表明，只要内源性阿片类物质的抑制作用已被消除，通过烟碱型乙酰胆碱受体的神经节传递对于蠕动反射可能并非必不可少。