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[人参中人参皂苷生物合成的研究成果]

[Research achievements on ginsenosides biosynthesis from Panax ginseng].

作者信息

Lin Yan-Ping, Zhang Mei-Ping, Wang Kang-Yu, Sun Chun-Yu, Wang Yi

机构信息

College of Life Science, Jilin Agricultural University, Changchun 130118, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2016 Dec;41(23):4292-4302. doi: 10.4268/cjcmm20162302.

DOI:10.4268/cjcmm20162302
PMID:28933103
Abstract

Panax ginseng is one of the famous rare medicinal herbs, and ginsenosides are the main active ingredient of ginseng is ginsenoside.They can be divided into three chemotypes: oleanane type, protopanaxadiol (PPD) type and the protopanaxatriol (PPT)type. Ginsenosides possess anti-thrombotic, anti-fatigue, anti-aging, cancer control, strengthening the immune system and many other effects. Rrogress has remarkably been made in pharmacology, efficacy and blosynthesis of ginsenosides.This review covers the recent research achievements of ginsenasides, which would be helpful for the relevant researchers to get useful information.

摘要

人参是著名的珍稀草药之一,人参皂苷是人参的主要活性成分。它们可分为三种化学类型:齐墩果烷型、原人参二醇(PPD)型和原人参三醇(PPT)型。人参皂苷具有抗血栓、抗疲劳、抗衰老、控制癌症、增强免疫系统等多种作用。人参皂苷在药理学、功效和生物合成方面取得了显著进展。本文综述了人参皂苷的最新研究成果,有助于相关研究人员获取有用信息。

相似文献

1
[Research achievements on ginsenosides biosynthesis from Panax ginseng].[人参中人参皂苷生物合成的研究成果]
Zhongguo Zhong Yao Za Zhi. 2016 Dec;41(23):4292-4302. doi: 10.4268/cjcmm20162302.
2
Characterization of Panax ginseng UDP-Glycosyltransferases Catalyzing Protopanaxatriol and Biosyntheses of Bioactive Ginsenosides F1 and Rh1 in Metabolically Engineered Yeasts.人参 UDP-糖基转移酶催化原人参三醇和生物活性人参皂苷 F1 和 Rh1 生物合成的特性及其在代谢工程酵母中的应用。
Mol Plant. 2015 Sep;8(9):1412-24. doi: 10.1016/j.molp.2015.05.010. Epub 2015 May 30.
3
Cytochrome P450 CYP716A53v2 catalyzes the formation of protopanaxatriol from protopanaxadiol during ginsenoside biosynthesis in Panax ginseng.细胞色素 P450 CYP716A53v2 在人参中催化人参皂苷生物合成过程中从原人参二醇形成原人参三醇。
Plant Cell Physiol. 2012 Sep;53(9):1535-45. doi: 10.1093/pcp/pcs106. Epub 2012 Aug 7.
4
Seasonal Variation and Possible Biosynthetic Pathway of Ginsenosides in Korean Ginseng Meyer.人参属植物中人参皂苷的季节性变化及可能的生物合成途径
Molecules. 2018 Jul 23;23(7):1824. doi: 10.3390/molecules23071824.
5
[The basic strategies and research advances in the studies on glycosyltransferases involved in ginsenoside biosynthesis].[人参皂苷生物合成中糖基转移酶研究的基本策略与研究进展]
Yao Xue Xue Bao. 2015 Feb;50(2):148-53.
6
Compound K Production from Red Ginseng Extract by β-Glycosidase from Sulfolobus solfataricus Supplemented with α-L-Arabinofuranosidase from Caldicellulosiruptor saccharolyticus.利用嗜热栖热菌β-糖苷酶从红参提取物中生产化合物K,并补充解纤维梭菌嗜热栖热亚种的α-L-阿拉伯呋喃糖苷酶。
PLoS One. 2015 Dec 28;10(12):e0145876. doi: 10.1371/journal.pone.0145876. eCollection 2015.
7
Modification of ginsenoside saponin composition via the CRISPR/Cas9-mediated knockout of protopanaxadiol 6-hydroxylase gene in .通过CRISPR/Cas9介导的原人参二醇6-羟化酶基因敲除对人参皂苷皂苷成分进行修饰
J Ginseng Res. 2022 Jul;46(4):505-514. doi: 10.1016/j.jgr.2021.06.004. Epub 2021 Jun 18.
8
Fungal sensitivity to and enzymatic deglycosylation of ginsenosides.真菌对人参皂苷的敏感性及其酶解糖化作用。
Phytochemistry. 2012 Jun;78:65-71. doi: 10.1016/j.phytochem.2012.02.027. Epub 2012 Mar 25.
9
Two ginseng UDP-glycosyltransferases synthesize ginsenoside Rg3 and Rd.两种人参UDP-糖基转移酶可合成人参皂苷Rg3和Rd。
Plant Cell Physiol. 2014 Dec;55(12):2177-88. doi: 10.1093/pcp/pcu147. Epub 2014 Oct 14.
10
Complete Biotransformation of Protopanaxatriol-Type Ginsenosides in Leaf Extract to Aglycon Protopanaxatriol by β-Glycosidases from and .人参三醇型人参皂苷在叶片提取物中通过来自[具体来源1]和[具体来源2]的β-糖苷酶完全生物转化为苷元人参三醇
J Microbiol Biotechnol. 2018 Feb 28;28(2):255-261. doi: 10.4014/jmb.1709.09053.

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Therapeutic potential and possible mechanisms of ginseng for depression associated with COVID-19.人参治疗 COVID-19 相关抑郁症的潜力及可能机制。
Inflammopharmacology. 2024 Feb;32(1):229-247. doi: 10.1007/s10787-023-01380-0. Epub 2023 Nov 27.
2
Progress on the Elucidation of the Antinociceptive Effect of Ginseng and Ginsenosides in Chronic Pain.人参及人参皂苷在慢性疼痛中镇痛作用的研究进展
Front Pharmacol. 2022 Feb 21;13:821940. doi: 10.3389/fphar.2022.821940. eCollection 2022.
3
Synergistic anti-liver cancer effects of curcumin and total ginsenosides.
姜黄素与总人参皂苷协同抗肝癌作用
World J Gastrointest Oncol. 2020 Oct 15;12(10):1091-1103. doi: 10.4251/wjgo.v12.i10.1091.
4
Hepatotoxicity of Herbal Supplements Mediated by Modulation of Cytochrome P450.草药补充剂通过调节细胞色素 P450 介导的肝毒性。
Int J Mol Sci. 2017 Nov 8;18(11):2353. doi: 10.3390/ijms18112353.