Wayne State University, Division of Cardiology, Detroit, Michigan, MI, United States.
University of Michigan, Division of Cardiology, Arrhythmia services, Ann Arbor, Michigan, MI, United States.
Curr Med Chem. 2019;26(5):855-863. doi: 10.2174/0929867324666170920151024.
MicroRNAs (miRNAs) are small non-coding RNAs, involved in regulation of post-transcriptional gene expression. They exert key role not only in physiology and normal development of the cardiovascular system but also in cardiovascular disease development and progression. Recent animal and human studies of tissue specific miRNAs have suggested a role in structural and electrical remodeling in atrial fibrillation (AF). Their emerging role as biomarkers and potential therapeutic targets in patients with AF is discussed in this review.
MicroRNAs (miRNAs) 是一种小型非编码 RNA，参与转录后基因表达的调控。它们不仅在心血管系统的生理和正常发育中发挥关键作用，而且在心血管疾病的发生和发展中也发挥作用。最近对组织特异性 miRNAs 的动物和人类研究表明，它们在心房颤动 (AF) 的结构和电重构中起作用。本文综述了它们作为 AF 患者的生物标志物和潜在治疗靶点的新兴作用。
