Pawlikowski M, Zelazowski P, Stepien H, Schally A V
Institute of Endocrinology, Medical Academy of Lodz, Poland.
Peptides. 1987 Sep-Oct;8(5):951-2. doi: 10.1016/0196-9781(87)90087-8.
The effect of somatostatin-14 (SST) and somatostatin analog D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-NH2 (RC-102) on migration inhibition of human leukocytes induced by cardiac antigen or phytohemagglutinin (PHA) was investigated. Both SST and RC-102 augmented the migration inhibition, thus indicating the enhanced formation or action of the leukocyte migration inhibiting factor (LMIF). This finding provides additional evidence for the immunomodulatory action of somatostatin.
研究了生长抑素-14（SST）和生长抑素类似物D-苯丙氨酸-半胱氨酸-苯丙氨酸-D-色氨酸-赖氨酸-苏氨酸-半胱氨酸-苏氨酸-NH2（RC-102）对心脏抗原或植物血凝素（PHA）诱导的人白细胞迁移抑制的影响。SST和RC-102均增强了迁移抑制，从而表明白细胞迁移抑制因子（LMIF）的形成或作用增强。这一发现为生长抑素的免疫调节作用提供了额外的证据。
