Pawlikowski M, Stepień H, Kunert-Radek J, Zelazowski P, Schally A V
Ann N Y Acad Sci. 1987;496:233-9. doi: 10.1111/j.1749-6632.1987.tb35771.x.
The influence of somatostatin (SST) on spontaneous proliferation and cyclic AMP level in mouse spleen lymphocytes and on inhibition of human leukocyte migration was studied. The rate of [3H]thymidine incorporation was used as an index of proliferation. It was found that lower concentrations of SST/10(-9) and 10(-8)M, inhibited the splenocyte proliferation. In contrast, a higher SST concentration, 10(-7)M, exerted a stimulatory effect. SST in concentrations from 10(-9) to 10(-6)M did not influence cyclic AMP levels in mouse splenocytes; a significant decrease of cyclic AMP was found after the exposure to superactive SST analog RC-102-2H in concentrations 10(-8) and 10(-7)M. SST, 10(-7)M, and RC-102-2H, 10(-7)M, significantly enhanced the migration inhibition of human leukocytes induced by the exposure of leukocytes to cardiac antigen or phytohemagglutinin. The data provide evidence for an immunomodulatory action of SST.
研究了生长抑素（SST）对小鼠脾脏淋巴细胞自发增殖、环磷酸腺苷（cAMP）水平以及对人白细胞迁移抑制的影响。以[3H]胸腺嘧啶核苷掺入率作为增殖指标。结果发现，较低浓度的SST/10(-9)和10(-8)M可抑制脾细胞增殖。相反，较高浓度的SST，即10(-7)M，则具有刺激作用。浓度为10(-9)至10(-6)M的SST对小鼠脾细胞中的cAMP水平无影响；在暴露于浓度为10(-8)和10(-7)M的超活性SST类似物RC-102-2H后，发现cAMP显著降低。10(-7)M的SST和10(-7)M的RC-102-2H可显著增强白细胞暴露于心脏抗原或植物血凝素后诱导的人白细胞迁移抑制作用。这些数据为SST的免疫调节作用提供了证据。
