a Department of Medical Biotechnology , School of Advanced Technologies in Medicine, Tehran University of Medical Sciences-International Campus (IC-TUMS) , Tehran , Iran.
b Immunology, Asthma & Allergy Research Institute (IAARI), Tehran University of Medical Sciences , Tehran , Iran.
Hum Vaccin Immunother. 2017 Oct 3;13(10):2428-2433. doi: 10.1080/21645515.2017.1365208.
More than 25% of the global population has IgE mediated allergic diseases. Allergen immunotherapy (AIT) is the only available form of treatment that alters the underlying mechanism of IgE-mediated allergic diseases. AIT is aimed at desensitizing allergic individuals by repeatedly administering disease-causing allergens over a long period of time. Despite its proven efficacy in numerous clinical trials, the effectiveness of AIT still suffers some drawbacks due to the quality of allergens used and in particular the unavailability of efficient allergen delivery systems. Several studies have demonstrated that bacterial ghosts (BG) systems can be used to display and deliver antigens to their targets for the management of diseases. However, there is no report documenting the use of BG systems for immunotherapy of IgE-mediated diseases so far. Thus, in this review, we intend to discuss the potentialities of BG systems for displaying and delivering allergens for future management of IgE-mediated diseases.
超过 25%的全球人口患有 IgE 介导的过敏性疾病。变应原免疫疗法（AIT）是唯一可改变 IgE 介导的过敏性疾病潜在机制的治疗方法。AIT 通过在很长一段时间内反复给予致病过敏原来使过敏个体脱敏。尽管在许多临床试验中已证明其疗效，但由于所用过敏原的质量以及特别是缺乏有效的过敏原传递系统，AIT 的有效性仍存在一些缺陷。多项研究表明，细菌噬菌体（BG）系统可用于显示和向其靶标传递抗原，以管理疾病。然而，迄今为止，尚无报道记录 BG 系统用于 IgE 介导疾病的免疫治疗。因此，在这篇综述中，我们旨在讨论 BG 系统用于显示和传递过敏原以用于未来 IgE 介导疾病的管理的潜力。
