Tomer R, Mintz M, Kempler S, Sigal M
Department of Psychiatry, University of Alberta, Edmonton, Canada.
Psychiatry Res. 1987 Dec;22(4):311-8. doi: 10.1016/0165-1781(87)90110-7.
Recent studies suggest that neuroleptic drugs may have an asymmetric effect on the two cerebral hemispheres. This effect is reflected by emergence of drug-induced lateralized extrapyramidal side effects and by dose-related alterations in electrophysiological asymmetries. The present study examined the hypothesis that asymmetry of visual evoked potentials (VEPs) is associated with lateralized appearance of neuroleptic-induced parkinsonism or tardive dyskinesia (TD). The asymmetry of the amplitudes of later VEP components was significantly higher in patients with lateralized side effects (n = 8) than in patients with symmetrical side effects (n = 6) or free of extrapyramidal side effects (n = 11). The possibility that VEP asymmetry reflects the differential degree to which the two hemispheres are affected by medication is discussed.
最近的研究表明，抗精神病药物可能对两个大脑半球产生不对称的影响。这种影响通过药物诱发的偏侧锥体外系副作用的出现以及电生理不对称的剂量相关改变得以体现。本研究检验了这样一个假设，即视觉诱发电位（VEP）的不对称与抗精神病药物诱发的帕金森症或迟发性运动障碍（TD）的偏侧出现有关。有偏侧副作用的患者（n = 8）中，VEP后期成分的波幅不对称性显著高于有对称副作用的患者（n = 6）或无锥体外系副作用的患者（n = 11）。文中讨论了VEP不对称反映两个半球受药物影响程度差异的可能性。
