Caligiuri M P, Lohr J B, Bracha H S, Jeste D V
Research Service, VA Medical Center, San Diego, CA 92161.
Biol Psychiatry. 1991 Jan 15;29(2):139-48. doi: 10.1016/0006-3223(91)90042-k.
We evaluated 21 right-handed psychiatric patients with tardive dyskinesia (TD) for the presence and laterality of neuroleptic-induced tremor and rigidity. The goals of the study were to assess the frequency and coexistence of TD and neuroleptic-induced parkinsonism (NIP) using instrumental and clinical measurements and to evaluate the hypothesis that when TD and NIP coexisted in the same patient, they were more likely to appear in opposite limbs. Results indicated that a high percentage of TD patients had coexisting rigidity and tremor on the basis of both clinical ratings and instrumental procedures; however, only instrumental procedures were useful in identifying tremor and rigidity asymmetries. We found that TD and tremor or rigidity did not lateralize to opposite limbs, thus weakening the hypothesis that TD and NIP stemmed from reciprocal pathophysiological mechanisms.
我们评估了21名患有迟发性运动障碍（TD）的右利手精神病患者，以确定抗精神病药物所致震颤和强直的存在情况及偏侧性。本研究的目的是通过仪器测量和临床评估来评估TD与抗精神病药物所致帕金森综合征（NIP）的发生率及共存情况，并评估以下假设：当TD和NIP在同一患者中共存时，它们更有可能出现在对侧肢体。结果表明，基于临床评分和仪器检查，高比例的TD患者同时存在强直和震颤；然而，只有仪器检查在识别震颤和强直不对称方面有用。我们发现，TD与震颤或强直并非偏向对侧肢体，因此削弱了TD和NIP源于相互病理生理机制的假设。
