Wang Shuangkun, Zuo Long, Jiang Tao, Peng Peng, Chu Shuilian, Xiao Dan
a Department of Radiology, Beijing Chao-Yang Hospital , Capital Medical University , Beijing , China.
b Clinical Research Center, Beijing Chao-Yang Hospital , Capital Medical University , Beijing , China.
Neurol Res. 2017 Dec;39(12):1094-1102. doi: 10.1080/01616412.2017.1379277. Epub 2017 Sep 21.
Objectives Cigarette smoking is an important risk factor of central nervous system diseases. However, the white matter (WM) integrity of early adulthood chronic smokers has not been attached enough importance to as it deserves, and the relationship between the chronic smoking effect and the WM is still unclear. The purpose of this study was to investigate whole - brain WM microstructure of early adulthood smokers and explore the structural correlates of behaviorally relevant features of the disorder. Methods We compared multiple DTI-derived indices, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD), between early adulthood smokers (n = 19) and age-, education- and gender-matched controls (n = 23) using a whole-brain tract-based spatial statistics approach. We also explored the correlations of the mean DTI index values with pack-years and Fagerström Test for Nicotine Dependence. Results The smokers showed increased FA in left superior longitudinal fasciculus (SLF), left anterior corona radiate, left superior corona radiate, left posterior corona radiate, left external capsule (EC), left inferior fronto-occipital fasciculus and sagittal stratum (SS), and decreased RD in left SLF. There were significant negative correlations among the average FA in the left external capsule and pack-years in smokers. In addition, significant positive correlation was found between RD values in the left SLF and pack-years. Discussion These findings indicate that smokers show microstructural changes in several white-matter regions. The correlation between the cumulative effect and microstructural WM alternations suggests that WM properties may become the new biomarkers in practice.
目的 吸烟是中枢神经系统疾病的重要危险因素。然而，成年早期慢性吸烟者的白质（WM）完整性尚未得到应有的充分重视，慢性吸烟效应与白质之间的关系仍不明确。本研究的目的是调查成年早期吸烟者的全脑白质微观结构，并探索该疾病行为相关特征的结构相关性。方法 我们使用基于全脑纤维束的空间统计学方法，比较了成年早期吸烟者（n = 19）与年龄、教育程度和性别匹配的对照组（n = 23）之间多个基于扩散张量成像（DTI）得出的指标，包括各向异性分数（FA）、平均扩散率（MD）、轴向扩散率（AD）和径向扩散率（RD）。我们还探讨了平均DTI指标值与吸烟包年数和尼古丁依赖的Fagerström测试之间的相关性。结果 吸烟者左侧上纵束（SLF）、左侧放射冠前部、左侧放射冠上部、左侧放射冠后部、左侧外囊（EC）、左侧额枕下束和矢状层（SS）的FA增加，左侧SLF的RD降低。吸烟者左侧外囊的平均FA与吸烟包年数之间存在显著负相关。此外，左侧SLF的RD值与吸烟包年数之间存在显著正相关。讨论 这些发现表明吸烟者在几个白质区域出现微观结构变化。累积效应与白质微观结构改变之间的相关性表明，白质特性可能成为实际中的新生物标志物。
