Li Xiang-Rong, Ren Yan-De, Cao Bo, Huang Xuan-Li
Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Province 530021, PR China.
Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, 266003, PR China.
Neurosci Lett. 2018 May 14;675:127-132. doi: 10.1016/j.neulet.2017.11.064. Epub 2017 Dec 1.
To analyze the microstructure of brain white matter according to diffusion tensor imaging (DTI) based on tract-based spatial statistics (TBSS) in early Parkinson's disease (PD).
A total of 31 age- and sex-matched early PD patients and 22 healthy volunteers were recruited in the present study. DTI was performed, and the data analyzed with fsl4.0 software. The fractional anisotropy (FA) was compared between both groups with an independent t test, and the differential area was analyzed. White matter fiber tracts with significant difference in FA between the two groups were selected, and their FAs were measured. Pearson's correlation analysis was employed to analyze the unified Parkinson's disease rating scale (UPDRS) score and its association with FA of different tracts.
When compared with healthy volunteers, early PD patients had reduced FA in the following areas: bilateral anterior corona radiate, upper corona radiate, fasciculus arcuatus, crus anterius capsulae internae, crus posterius capsulae internae, capsula externa, posterior thalamic radiation, optic radiation, sagittal layer (including fasciculus arcuatus and inferior fronto-occipital fasciculus), crura fornicis, stria terminalis, fornix, genu, body and pad of corpus callosum, left unciform fasciculus, right cingulate bundle, right medipeduncle, and arcuate fibers in the bilateral frontal, temporal, and occipital lobes (P < 0.05). When compared with healthy volunteers, early PD patients showed abnormal FA of fasciculus in the white matter mainly in following areas: bilateral crus anterius capsulae internae, bilateral capsula externa, right anterior corona radiate, body and pad of bilateral corpus callosum, and left sagittal layer (including fasciculi longitudinalis inferior and fasciculus occipitofrontalis inferior) (P < 0.05). In addition, in early PD patients, the UPDRS score and movement score had no relationship with the FA of different fasciculi in the white matter (P > 0.05).
There is wide alteration of white matter microstructure in early PD patients, which is characterized by disruption of projection fibers in the descending pathway, limbic system-related fasciculi, corpus callosum, thalamus after radiation, posterior thalamic radiation, Gratiolet's bundle and other fasciculi in the white matter.
基于基于纤维束的空间统计（TBSS）的扩散张量成像（DTI）分析早期帕金森病（PD）患者脑白质的微观结构。
本研究共纳入31例年龄和性别匹配的早期PD患者及22名健康志愿者。进行DTI检查，并使用fsl4.0软件对数据进行分析。采用独立t检验比较两组间的分数各向异性（FA），并分析差异区域。选取两组间FA有显著差异的白质纤维束，测量其FA值。采用Pearson相关分析分析统一帕金森病评定量表（UPDRS）评分及其与不同纤维束FA值的相关性。
与健康志愿者相比，早期PD患者在以下区域FA值降低：双侧放射冠前部、放射冠上部、弓状束、内囊前肢、内囊后肢、外囊、丘脑后辐射、视辐射、矢状层（包括弓状束和额枕下束）、穹窿脚、终纹、穹窿、胼胝体膝部、体部和压部、左侧钩束、右侧扣带束、右侧脑桥脚以及双侧额叶、颞叶和枕叶的弓状纤维（P<0.05）。与健康志愿者相比，早期PD患者白质中主要在以下区域的纤维束FA值异常：双侧内囊前肢、双侧外囊、右侧放射冠前部、双侧胼胝体体部和压部以及左侧矢状层（包括下纵束和额枕下束）（P<0.05）。此外，在早期PD患者中，UPDRS评分和运动评分与白质中不同纤维束的FA值无关（P>0.05）。
早期PD患者白质微观结构存在广泛改变，其特征为下行通路、边缘系统相关纤维束、胼胝体、丘脑辐射后、丘脑后辐射、Gratiolet束及其他白质纤维束中的投射纤维中断。
