Delabaere A, Curinier S, Ughetto S, Gibold L, Bonnet R, Rossi A, Gallot D
Retinoids, development and developmental diseases, EA 7281, medicine school, Auvergne university, 28, place Henri-Dunant, BP 38, 63001 Clermont-Ferrand cedex 1, France; Department of obstetrics and gynecology, university hospital, 1, place Lucie-et-Raymond-Aubrac, 63000 Clermont-Ferrand, France.
Department of obstetrics and gynecology, university hospital, 1, place Lucie-et-Raymond-Aubrac, 63000 Clermont-Ferrand, France.
J Gynecol Obstet Hum Reprod. 2017 May;46(5):449-453. doi: 10.1016/j.jogoh.2017.03.010. Epub 2017 Apr 5.
To decrease the incidence of early-onset group B streptococcal (GBS) disease, a culture-based screening of all pregnant women at 35-37 weeks is recommended. This gold standard test requires 24-72hours culture. This delay precludes its use for intrapartum screening. This study assesses a new immunoassay, the DIMA test, for identifying GBS-positive patients in the labor ward.
This was a prospective observational study of 195 pregnant women presenting with full-term labor at a single site in France between June and August 2012. We assessed the diagnostic accuracy of intrapartum DIMA testing as compared to intrapartum GBS culture and prenatal screening at 35-38 weeks.
The DIMA test sensitivity and specificity were 57.1% and 83.2%, respectively, as compared to 42.9% and 97% for prenatal culture screening.
The DIMA test assay is a rapid and inexpensive test for the detection of maternal GBS colonization in the labor ward. Its sensitivity is higher than antepartum culture but its specificity is lower. Its performance was inferior to that reported for rapid polymerase chain reaction assays.
为降低早发型B族链球菌（GBS）疾病的发病率，建议对所有孕周为35 - 37周的孕妇进行基于培养的筛查。这项金标准检测需要24 - 72小时的培养时间。这种延迟使其无法用于产时筛查。本研究评估一种新的免疫测定法——DIMA检测法，用于识别产房内GBS阳性患者。
这是一项前瞻性观察性研究，研究对象为2012年6月至8月间在法国某一地点足月分娩的195名孕妇。我们评估了产时DIMA检测相对于产时GBS培养及35 - 38周产前筛查的诊断准确性。
与产前培养筛查的42.9%和97%相比，DIMA检测的敏感性和特异性分别为57.1%和83.2%。
DIMA检测法是一种用于检测产房内孕妇GBS定植的快速且廉价的检测方法。其敏感性高于产前培养，但特异性较低。其性能低于快速聚合酶链反应检测法所报告的性能。
