Armario A, Garcia-Marquez C, Jolin T
Departamento de Biología Celular y Fisiología, Universidad Autónoma de Barcelona, Spain.
Psychoneuroendocrinology. 1987;12(5):399-406. doi: 10.1016/0306-4530(87)90069-2.
The effect of chronic stress on basal and stress-induced alterations of TSH and GH was studied in adult male rats. Chronically stressed rats were subjected 6 days per week for 4 weeks to several acute stressors including saline injections, noise, ether and forced swimming. Each day, one stressor was chosen randomly. Twenty hr after the last stress session, basal levels of TSH were normal or increased, with no altered pituitary response to TRH. In contrast, the TSH rise induced by acute stress was blunted in chronically stressed rats. Chronic stress resulted in lower basal and acute stress levels of GH. These modifications were probably due to changes in the release of hypothalamic regulatory hormones, because no evidence for altered TSH response to TRH, and GH response either to GHRH or to somatostatin, was found. Some abnormal responses of GH to TRH and of TSH to GHRH were observed in chronically stressed rats. These data indicate that this type of chronic stress induced significant changes in basal and acute stress levels of GH and TSH in the rat.
研究了慢性应激对成年雄性大鼠促甲状腺激素（TSH）和生长激素（GH）基础水平及应激诱导变化的影响。慢性应激大鼠每周6天、持续4周接受包括盐水注射、噪音、乙醚和强迫游泳在内的多种急性应激源刺激。每天随机选择一种应激源。在最后一次应激刺激后20小时，TSH基础水平正常或升高，垂体对促甲状腺激素释放激素（TRH）的反应未改变。相比之下，慢性应激大鼠中急性应激诱导的TSH升高减弱。慢性应激导致GH基础水平和急性应激水平降低。这些改变可能是由于下丘脑调节激素释放的变化，因为未发现TSH对TRH反应以及GH对生长激素释放激素（GHRH）或生长抑素反应改变的证据。在慢性应激大鼠中观察到GH对TRH以及TSH对GHRH的一些异常反应。这些数据表明，这种类型的慢性应激在大鼠中诱导了GH和TSH基础水平及急性应激水平的显著变化。
