Laboratory of Molecular Microbiology, Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan.
FEMS Yeast Res. 2017 Nov 1;17(7). doi: 10.1093/femsyr/fox066.
Ecl1 family genes are conserved among yeast, in which their overexpression extends chronological lifespan. Ecl1 family genes were first identified in the fission yeast Schizosaccharomyces pombe; at the time, they were considered noncoding RNA owing to their short coding sequence of fewer than 300 base pairs. Schizosaccharomyces pombe carries three Ecl1 family genes, ecl1+, ecl2+ and ecl3+, whereas Saccharomyces cerevisiae has one, ECL1. Their overexpression extends chronological lifespan, increases oxidative stress resistance and induces sexual development in fission yeast. A recent study indicated that Ecl1 family genes play a significant role in responding to environmental zinc or sulfur depletion. In this review, we focus on Ecl1 family genes in fission yeast and describe the relationship between nutritional depletion and cellular output, as the latter depends on Ecl1 family genes. Furthermore, we present the roles and functions of Ecl1 family genes characterized to date.
Ecl1 家族基因在酵母中是保守的，其过表达能延长酵母的时序寿命。Ecl1 家族基因最初在裂殖酵母 Schizosaccharomyces pombe 中被鉴定出来；当时，由于其编码序列少于 300 个碱基对，被认为是非编码 RNA。裂殖酵母 Schizosaccharomyces pombe 有三个 Ecl1 家族基因 ecl1+、ecl2+和 ecl3+，而酿酒酵母 Saccharomyces cerevisiae 只有一个 ECL1。它们的过表达能延长酵母的时序寿命，提高其对氧化应激的抗性，并诱导裂殖酵母的有性发育。最近的一项研究表明，Ecl1 家族基因在响应环境中锌或硫的缺乏方面起着重要作用。在这篇综述中，我们主要关注裂殖酵母中的 Ecl1 家族基因，并描述营养物质耗尽与细胞输出之间的关系，因为后者依赖于 Ecl1 家族基因。此外，我们还介绍了迄今为止所鉴定的 Ecl1 家族基因的作用和功能。
