孕期胎盘而非外周血感染恶性疟原虫与婴儿期疟疾风险增加有关。
Placental but Not Peripheral Plasmodium falciparum Infection During Pregnancy Is Associated With Increased Risk of Malaria in Infancy.
作者信息
Boudová Sarah, Divala Titus, Mungwira Randy, Mawindo Patricia, Tomoka Tamiwe, Laufer Miriam K
机构信息
Division of Malaria Research, Institute for Global Health, University of Maryland School of Medicine, Baltimore.
Blantyre Malaria Project.
出版信息
J Infect Dis. 2017 Sep 15;216(6):732-735. doi: 10.1093/infdis/jix372.
Abstract
Pregnancy-associated Plasmodium falciparum infection impacts the health of mothers and newborns, but little is known about the effects of these infections on infant susceptibility to malaria. We followed 473 mother-infant pairs during pregnancy and through 2 years of age. We observed that children born to mothers with placental malaria, but not those born to mothers with peripheral infection without evidence of placental sequestration, had increased risk of malaria during the first year of life compared with children born to mothers with no malaria during pregnancy. Malaria infections with placental sequestration have long-lasting impact on infant susceptibility to malaria infection.
摘要
妊娠相关的恶性疟原虫感染会影响母亲和新生儿的健康，但对于这些感染对婴儿疟疾易感性的影响却知之甚少。我们在孕期及婴儿两岁前对473对母婴进行了跟踪研究。我们观察到，与孕期未感染疟疾的母亲所生的孩子相比，胎盘疟疾母亲所生的孩子在出生后第一年感染疟疾的风险增加，而外周感染但无胎盘滞留证据的母亲所生的孩子则没有这种情况。伴有胎盘滞留的疟疾感染对婴儿疟疾易感性有长期影响。
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