Levine Min Z, Holiday Crystal, Liu Feng, Jefferson Stacie, Gillis Eric, Bellamy Abbie R, Tumpey Terrence, Katz Jacqueline M
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Statistical and Data Coordinating Center, Emmes Corporation, Rockville, Maryland.
J Infect Dis. 2017 Sep 15;216(suppl_4):S555-S559. doi: 10.1093/infdis/jix001.
Recently, novel highly pathogenic avian influenza H5Nx viruses (clade 2.3.4.4) caused outbreaks in US poultry. We evaluated the potential of a stockpiled A(H5N1) A/Anhui/1/2005 (clade 2.3.4) vaccine to elicit cross-reactive antibody responses to these emerging viruses. Sera from subjects who received 2 doses of MF59-adjuvanted A/Anhui/1/2005, or 1 dose of MF59-adjuvanted A/Anhui/1/2005 following priming with a clade 1 vaccine were characterized by microneutralization assays and modified hemagglutination inhibition (HI) assays. Only heterologous prime-boost vaccination induced modest cross-reactive HI antibody responses to H5Nx viruses. Heterologous prime-boost may provide a more effective vaccination strategy to broaden the antibody responses to emerging viruses.
最近，新型高致病性禽流感H5Nx病毒（2.3.4.4分支）在美国家禽中引发了疫情。我们评估了储备的A(H5N1) A/安徽/1/2005（2.3.4分支）疫苗引发针对这些新出现病毒的交叉反应性抗体反应的潜力。通过微量中和试验和改良血凝抑制（HI）试验对接受2剂MF59佐剂A/安徽/1/2005疫苗的受试者血清，或在接种1型疫苗初免后再接种1剂MF59佐剂A/安徽/1/2005疫苗的受试者血清进行了表征。只有异源初免-加强免疫接种诱导了对H5Nx病毒适度的交叉反应性HI抗体反应。异源初免-加强免疫可能提供一种更有效的疫苗接种策略，以扩大对新出现病毒的抗体反应。
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