Gossai Anala, Zens M Scot, Punshon Tracy, Jackson Brian P, Perry Ann E, Karagas Margaret R
Department of Epidemiology, Geisel School of Medicine at Dartmouth , Hanover, New Hampshire, USA.
Department of Biological Sciences, Dartmouth College , Hanover, New Hampshire, USA.
Environ Health Perspect. 2017 Sep 7;125(9):097005. doi: 10.1289/EHP1065.
Rice contains arsenic, a known skin carcinogen. Rice intake has been associated with arsenic-related skin lesions in South Asia, but its association with skin cancers is as yet unknown.
We aimed to investigate whether rice intake contributes to urinary arsenic concentration and risk of squamous cell carcinoma (SCC) of the skin in a U.S. population.
Rice consumption was assessed using a food frequency questionnaire administered as part of a population-based case-control study of 487 SCC cases and 462 age- and gender-matched controls. Arsenic concentration in household tap water and urine samples were measured using inductively coupled mass spectrometry (ICP-MS) and high-resolution ICP-MS, respectively. Odds ratios (OR) for SCC associated with the frequency of rice consumption were estimated using logistic regression, with adjustment for age, gender, and caloric intake.
Those who reported any rice consumption had higher urinary arsenic concentrations than those who did not consume rice, and the association was most pronounced among those with <1μg/L arsenic in their household water (19.2% increase in total urinary arsenic, 95% CI: 5.0, 35.3%). Any rice consumption was associated with a 1.5-fold (95% CI: 1.1, 2.0) higher odds of SCC compared with those who reported no rice consumption, and the relation appeared to be largely among those with <1μg/L water arsenic.
Rice consumption may be related to the occurrence of SCC in the United States, especially among those with relatively low drinking water arsenic exposure. https://doi.org/10.1289/EHP1065.
大米含有砷，一种已知的皮肤致癌物。在南亚，大米摄入与砷相关的皮肤病变有关，但其与皮肤癌的关联尚不清楚。
我们旨在调查在美国人群中，大米摄入是否会导致尿砷浓度升高以及患皮肤鳞状细胞癌（SCC）的风险增加。
通过食物频率问卷评估大米摄入量，该问卷是一项基于人群的病例对照研究的一部分，该研究纳入了487例SCC病例和462例年龄及性别匹配的对照。分别使用电感耦合质谱（ICP-MS）和高分辨率ICP-MS测量家庭自来水和尿液样本中的砷浓度。使用逻辑回归估计与大米消费频率相关的SCC的优势比（OR），并对年龄、性别和热量摄入进行调整。
报告食用过任何大米的人的尿砷浓度高于未食用大米的人，这种关联在家庭用水中砷含量<1μg/L的人群中最为明显（总尿砷增加19.2%，95%CI：5.0，35.3%）。与报告未食用大米的人相比，食用任何大米与SCC的患病几率高1.5倍（95%CI：1.1，2.0）相关，这种关系似乎主要存在于家庭用水砷含量<1μg/L的人群中。
在美国，食用大米可能与SCC的发生有关，尤其是在饮用水砷暴露相对较低的人群中。https://doi.org/10.1289/EHP1065
