Madden D L, Tzan N R, Roman G C, Detels R, Mundon F K, Fuccillo D A, Sever J L
Infectious Disease Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland 20892.
Yale J Biol Med. 1987 Nov-Dec;60(6):569-74.
To investigate the possible occurrence of human immunodeficiency virus (HIV) or human T-cell lymphotropic virus, type I (HTLV-I) infections in the United States prior to 1979-1981, when acquired immune deficiency syndrome (AIDS) was first recognized, we tested sera from 310 pregnant women who participated in the Collaborative Perinatal Project during the period 1959-1964 for HIV and HTLV-I antibody. These samples included sera from 53 pregnant women who were intravenous drug users. The remainder were from women who had cervical epithelial abnormalities, who developed cervical carcinomas, who had had children with erythroblastosis fetalis, who had had children that developed malignant neoplasms early in life, or normal pregnant women. None of the 310 women had confirmed HIV or HTLV-I antibody. The rate of false-positive reactions with the HIV enzyme-linked immunosorbent assay (ELISA) antibody test in these long-frozen samples was similar to that observed in fresh sera. HIV antibody was detected in homosexual patients with AIDS; HTLV-I antibody was not detected in any of these sera. HTLV-I antibody was detected in 17 of 20 patients with tropical spastic paraparesis (TSP) and in two of seven patients with other neurological diseases diagnosed as transverse myelopathy and multiple sclerosis, and in none of nine normal controls; HIV antibody was not detected in any of these sera patients. Thus, we conclude that there was no serological evidence of infection with HIV or HTLV-I in the pregnant women studied; however, HIV antibody was present in all AIDS patients tested, and HTLV-I antibody was found in the majority of patients with TSP.
为了调查在1979 - 1981年首次确认获得性免疫缺陷综合征（艾滋病）之前美国是否可能发生过人类免疫缺陷病毒（HIV）或I型人类嗜T淋巴细胞病毒（HTLV - I）感染，我们检测了1959 - 1964年期间参与围产期协作项目的310名孕妇的血清，以检测HIV和HTLV - I抗体。这些样本包括53名静脉吸毒孕妇的血清。其余血清来自患有宫颈上皮异常、患宫颈癌、生育过患有胎儿成红细胞增多症的孩子、生育过早发恶性肿瘤孩子的妇女或正常孕妇。310名妇女中无一例确诊感染HIV或HTLV - I抗体。这些长期冷冻样本中HIV酶联免疫吸附测定（ELISA）抗体检测的假阳性反应率与新鲜血清中观察到的相似。在患有艾滋病的同性恋患者中检测到了HIV抗体；在这些血清中均未检测到HTLV - I抗体。在20例热带痉挛性截瘫（TSP）患者中的17例、7例被诊断为横贯性脊髓炎和多发性硬化等其他神经系统疾病患者中的2例检测到了HTLV - I抗体，9名正常对照中均未检测到；在这些血清患者中均未检测到HIV抗体。因此，我们得出结论，在所研究的孕妇中没有感染HIV或HTLV - I的血清学证据；然而，在所有检测的艾滋病患者中均存在HIV抗体，并且在大多数TSP患者中发现了HTLV - I抗体。
