Zhang Shaowei, Xue Zhiqiang
Department of Toracic Surgery, PLA General Hospital, Beijing 100853, China.
Zhongguo Fei Ai Za Zhi. 2017 Sep 20;20(9):635-640. doi: 10.3779/j.issn.1009-3419.2017.09.08.
Lung cancer is becoming an increasing threat to Chinese residents and its incidence continues to rise while the treatment effect is far from satisfactory. Hence, it is essential to improve the level of early diagnosis, treatment, prognosis in lung cancer. An epigenetic trait is a stably heritable phenotype resulting from changes in a chromosome without alterations in the DNA sequence. The epigenetic studies, such as DNA methylation and histone methylation, are progressing rapidly in oncology research. A comprehensive understanding of its development status and existing problems is of great significance for the future research and the implementation of precision medicine. Herein, we aim to outline the progress of DNA methylation and histone methylation modification in lung cancer and make a prospect for the future research.
肺癌正日益威胁着中国居民，其发病率持续上升，而治疗效果却远不尽人意。因此，提高肺癌的早期诊断、治疗及预后水平至关重要。表观遗传特征是指染色体发生变化而DNA序列未改变时产生的一种稳定可遗传的表型。诸如DNA甲基化和组蛋白甲基化等表观遗传学研究在肿瘤学研究中进展迅速。全面了解其发展现状和存在的问题对于未来的研究及精准医学的实施具有重要意义。在此，我们旨在概述肺癌中DNA甲基化和组蛋白甲基化修饰的研究进展，并对未来研究进行展望。
