独立于血压降低动脉僵硬度：VaSera试验 - Suppr

Reducing Arterial Stiffness Independently of Blood Pressure: The VaSera Trial.

作者信息

Mills Charlotte E, Govoni Virginia, Faconti Luca, Casagrande Maria-Linda, Morant Steven V, Webb Andrew J, Cruickshank J Kennedy

出版信息

J Am Coll Cardiol. 2017 Sep 26;70(13):1683-1684. doi: 10.1016/j.jacc.2017.07.765.

DOI:10.1016/j.jacc.2017.07.765

PMID:28935045

Abstract

摘要

相似文献

Reducing Arterial Stiffness Independently of Blood Pressure: The VaSera Trial.独立于血压降低动脉僵硬度：VaSera试验

J Am Coll Cardiol. 2017 Sep 26;70(13):1683-1684. doi: 10.1016/j.jacc.2017.07.765.

A randomised, factorial trial to reduce arterial stiffness independently of blood pressure: Proof of concept? The VaSera trial testing dietary nitrate and spironolactone.一项旨在独立于血压降低动脉僵硬度的随机析因试验：概念验证？VaSera试验对膳食硝酸盐和螺内酯进行测试。

Br J Clin Pharmacol. 2020 May;86(5):891-902. doi: 10.1111/bcp.14194. Epub 2020 Feb 22.

Cardiac effects of 6 months' dietary nitrate and spironolactone in patients with hypertension and with/at risk of type 2 diabetes, in the factorial design, double-blind, randomized controlled VaSera trial.在因子设计、双盲、随机对照 VaSera 试验中，研究了 6 个月饮食硝酸盐和螺内酯对高血压伴/有 2 型糖尿病风险患者的心脏影响。

Br J Clin Pharmacol. 2019 Jan;85(1):169-180. doi: 10.1111/bcp.13783. Epub 2018 Nov 13.

Spironolactone Reduces Aortic Stiffness in Patients With Resistant Hypertension Independent of Blood Pressure Change.螺内酯可降低高血压患者的主动脉僵硬度，与血压变化无关。

J Am Heart Assoc. 2021 Sep 7;10(17):e019434. doi: 10.1161/JAHA.120.019434. Epub 2021 Aug 28.

The usefulness of a single arm cuff oscillometric method (Arteriograph) to assess changes in central aortic blood pressure and arterial stiffness by antihypertensive treatment: results from the Doxazosin-Ramipril Study.采用单臂袖带示波法（动脉血压计）评估降压治疗对中心主动脉血压和动脉僵硬度的影响：多沙唑嗪-雷米普利研究结果

Blood Press. 2018 Apr;27(2):88-98. doi: 10.1080/08037051.2017.1394791. Epub 2017 Oct 26.

Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies.耐药性高血压的内分泌和血液动力学变化，以及螺内酯或阿米洛利对血压的反应：PATHWAY-2 机制子研究。

Lancet Diabetes Endocrinol. 2018 Jun;6(6):464-475. doi: 10.1016/S2213-8587(18)30071-8. Epub 2018 Apr 11.

Dietary nitrate prevents progression of carotid subclinical atherosclerosis through blood pressure-independent mechanisms in patients with or at risk of type 2 diabetes mellitus.饮食硝酸盐通过独立于血压的机制预防 2 型糖尿病或有 2 型糖尿病风险患者的颈动脉亚临床动脉粥样硬化进展。

Br J Clin Pharmacol. 2021 Dec;87(12):4726-4736. doi: 10.1111/bcp.14897. Epub 2021 May 29.

[PATHWAY-2 Study: spironolactone vs placebo, bisoprolol and doxazosin to determine optimal treatment of resistant hypertension. Spironolactone high effective in lowering blood pressure in drug resistant hypertension].[PATHWAY-2研究：螺内酯与安慰剂、比索洛尔和多沙唑嗪对比以确定难治性高血压的最佳治疗方案。螺内酯在降低难治性高血压患者血压方面疗效显著]

Vnitr Lek. 2015 Dec;61(12):1067-71.

Spironolactone and doxazosin treatment in patients with resistant hypertension.螺内酯与多沙唑嗪治疗顽固性高血压患者

Rev Esp Cardiol. 2009 Feb;62(2):158-66. doi: 10.1016/s1885-5857(09)71534-8.

Effect of oral nitrates on pulse pressure and arterial elasticity in patients aged over 65 years with refractory isolated systolic hypertension: study protocol for a randomized controlled trial.口服硝酸盐对65岁以上难治性单纯收缩期高血压患者脉压和动脉弹性的影响：一项随机对照试验的研究方案

Trials. 2013 Nov 14;14:388. doi: 10.1186/1745-6215-14-388.

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Oral nitrate supplementation improves cardiovascular risk markers in COPD: ON-BC, a randomised controlled trial.口服硝酸盐补充剂可改善 COPD 的心血管风险标志物：ON-BC，一项随机对照试验。

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Associations between air pollutants and blood pressure in an ethnically diverse cohort of adolescents in London, England.在英格兰伦敦的一个种族多样化的青少年队列中，空气污染物与血压之间的关联。

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Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes.高浓度的 eNAMPT 在结构和功能上的变化介导了 2 型糖尿病小鼠和人胰岛β细胞功能障碍。

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Arterial Stiffness Can Be Modulated by Pressure-Independent Mechanisms in Hypertension.高血压患者的动脉僵硬度可通过压力非依赖性机制进行调节。

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