McLenachan J M, Findlay I N, Henderson E, Wilson J T, Dargie H J
Cardiac Department, Western Infirmary, Glasgow, Scotland.
Am J Cardiol. 1988 Feb 10;61(5):52C. doi: 10.1016/0002-9149(88)90486-9.
Once-daily atenolol and celiprolol were compared in a placebo-controlled crossover study of 16 patients with stable angina pectoris. Atenolol and celiprolol equally and significantly reduced frequency of angina and electrocardiographic evidence of cardiac ischemia. Celiprolol, however, produced less suppression of the double product at 1 mm of ST-segment depression than atenolol, suggesting that actions other than reduction of heart rate may contribute to its antianginal efficacy.
在一项针对16例稳定型心绞痛患者的安慰剂对照交叉研究中，对每日服用一次的阿替洛尔和塞利洛尔进行了比较。阿替洛尔和塞利洛尔在同等程度上显著降低了心绞痛发作频率以及心脏缺血的心电图证据。然而，在ST段压低1毫米时，塞利洛尔对双乘积的抑制作用小于阿替洛尔，这表明除降低心率外的其他作用可能有助于其抗心绞痛疗效。
