β受体阻滞剂辅助特性在心绞痛治疗中的重要性：塞利洛尔与阿替洛尔的研究
Importance of ancillary properties of beta blockers in angina: a study of celiprolol and atenolol.
作者信息
McLenachan J M, Wilson J T, Dargie H J
机构信息
Department of Cardiology, Western Infirmary, Glasgow.
出版信息
Br Heart J. 1988 Jun;59(6):685-9. doi: 10.1136/hrt.59.6.685.
Abstract
Celiprolol (400 mg) and atenolol (100 mg) were given once a day to 16 patients with stable angina pectoris in a double blind placebo controlled crossover study. Celiprolol produced less suppression of heart rate both at rest and during exercise than atenolol. Both drugs were equally effective in reducing the frequency of angina and in delaying the onset of ischaemia during exercise. Radionuclide ventriculography showed that atenolol but not celiprolol lowered cardiac output at rest and during exercise. Thus the ancillary properties of celiprolol, including partial beta 2 agonist activity and direct vasodilating activity, have detectable effects on cardiac function that may be beneficial in patients with angina.
摘要
在一项双盲安慰剂对照交叉研究中，对16例稳定型心绞痛患者每天给药一次，分别给予塞利洛尔（400毫克）和阿替洛尔（100毫克）。与阿替洛尔相比，塞利洛尔在静息和运动时对心率的抑制作用较小。两种药物在减少心绞痛发作频率和延缓运动时缺血发作方面同样有效。放射性核素心室造影显示，阿替洛尔而非塞利洛尔可降低静息和运动时的心输出量。因此，塞利洛尔的辅助特性，包括部分β2激动剂活性和直接血管舒张活性，对心脏功能有可检测到的影响，这可能对心绞痛患者有益。
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