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Clinical implications of somatic mutations in aplastic anemia and myelodysplastic syndrome in genomic age.基因组时代骨髓增生异常综合征和再生障碍性贫血体细胞突变的临床意义。
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本文引用的文献

1
Dynamics of clonal evolution in myelodysplastic syndromes.骨髓增生异常综合征的克隆进化动力学
Nat Genet. 2017 Feb;49(2):204-212. doi: 10.1038/ng.3742. Epub 2016 Dec 19.
2
DNMT3A in haematological malignancies.血液系统恶性肿瘤中的DNA甲基转移酶3A（DNMT3A）
Nat Rev Cancer. 2015 Mar;15(3):152-65. doi: 10.1038/nrc3895. Epub 2015 Feb 19.
3
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence.从血液DNA序列推断克隆性造血与血癌风险。
N Engl J Med. 2014 Dec 25;371(26):2477-87. doi: 10.1056/NEJMoa1409405. Epub 2014 Nov 26.
4
Age-related clonal hematopoiesis associated with adverse outcomes.与不良预后相关的年龄相关性克隆性造血。
N Engl J Med. 2014 Dec 25;371(26):2488-98. doi: 10.1056/NEJMoa1408617. Epub 2014 Nov 26.
5
Age-related mutations associated with clonal hematopoietic expansion and malignancies.与克隆性造血扩张和恶性肿瘤相关的年龄相关突变。
Nat Med. 2014 Dec;20(12):1472-8. doi: 10.1038/nm.3733. Epub 2014 Oct 19.
6
The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers.R882H DNMT3A 突变与 AML 相关，通过阻断其形成活性四聚体的能力，显性抑制野生型 DNMT3A。
Cancer Cell. 2014 Apr 14;25(4):442-54. doi: 10.1016/j.ccr.2014.02.010. Epub 2014 Mar 20.
7
A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells.一种在 AML 中常见的 DNMT3A 突变在鼠胚胎干细胞中表现出显性负效应。
Blood. 2013 Dec 12;122(25):4086-9. doi: 10.1182/blood-2013-02-483487. Epub 2013 Oct 28.
8
Landmark analysis of DNMT3A mutations in hematological malignancies.血液系统恶性肿瘤中DNMT3A突变的标志性分析。
Leukemia. 2013 Jul;27(7):1573-8. doi: 10.1038/leu.2013.65. Epub 2013 Mar 1.
9
The role of mutations in epigenetic regulators in myeloid malignancies.基因突变在髓系恶性肿瘤中表观遗传学调控中的作用。
Nat Rev Cancer. 2012 Sep;12(9):599-612. doi: 10.1038/nrc3343. Epub 2012 Aug 17.
10
Mutations in DNA methyltransferase (DNMT3A) observed in acute myeloid leukemia patients disrupt processive methylation.在急性髓系白血病患者中观察到的 DNA 甲基转移酶（DNMT3A）突变会破坏连续性甲基化。
J Biol Chem. 2012 Sep 7;287(37):30941-51. doi: 10.1074/jbc.M112.366625. Epub 2012 Jun 21.

Distinct clinical and biological implications of various DNMT3A mutations in myeloid neoplasms.

作者信息

Balasubramanian S K, Aly M, Nagata Y, Bat T, Przychodzen B P, Hirsch C M, Adema V, Visconte V, Kuzmanovic T, Radivoyevitch T, Nazha A, Mukherjee S, Sekeres M A, Maciejewski J P

机构信息

Department of Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, OH, USA.

Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.

出版信息

Leukemia. 2018 Feb;32(2):550-553. doi: 10.1038/leu.2017.295. Epub 2017 Sep 22.

DOI:10.1038/leu.2017.295
PMID:28935992
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8404553/
Abstract
摘要