Distinct clinical and biological implications of various DNMT3A mutations in myeloid neoplasms.
作者信息
Balasubramanian S K, Aly M, Nagata Y, Bat T, Przychodzen B P, Hirsch C M, Adema V, Visconte V, Kuzmanovic T, Radivoyevitch T, Nazha A, Mukherjee S, Sekeres M A, Maciejewski J P
机构信息
Department of Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, OH, USA.
Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
出版信息
Leukemia. 2018 Feb;32(2):550-553. doi: 10.1038/leu.2017.295. Epub 2017 Sep 22.
Abstract
摘要
相似文献
1
Distinct clinical and biological implications of various DNMT3A mutations in myeloid neoplasms.髓系肿瘤中各种DNMT3A突变的不同临床和生物学意义。
Leukemia. 2018 Feb;32(2):550-553. doi: 10.1038/leu.2017.295. Epub 2017 Sep 22.
2
DNMT3A mutations in acute myeloid leukemia: stability during disease evolution and clinical implications.DNMT3A 突变在急性髓细胞白血病中的作用：疾病演变过程中的稳定性及其临床意义。
Blood. 2012 Jan 12;119(2):559-68. doi: 10.1182/blood-2011-07-369934. Epub 2011 Nov 10.
3
DNMT3A mutations are rare in childhood acute myeloid leukemia.DNA甲基转移酶3A（DNMT3A）突变在儿童急性髓系白血病中较为罕见。
Haematologica. 2011 Aug;96(8):1238-40. doi: 10.3324/haematol.2011.046839. Epub 2011 Jun 17.
4
DNMT3A mutations in AML: a new prognostic factor?急性髓系白血病中的DNMT3A突变：一种新的预后因素？
Leuk Res. 2013 Nov;37(11):1432-3. doi: 10.1016/j.leukres.2013.08.012. Epub 2013 Sep 6.
5
Rapid detection of DNMT3A R882 codon mutations allows early identification of poor risk patients with acute myeloid leukemia.快速检测DNMT3A R882密码子突变可实现对急性髓系白血病低危患者的早期识别。
Leuk Lymphoma. 2013 Jun;54(6):1336-9. doi: 10.3109/10428194.2012.736986. Epub 2012 Nov 1.
6
FLT3-ITD Compared with DNMT3A R882 Mutation Is a More Powerful Independent Inferior Prognostic Factor in Adult Acute Myeloid Leukemia Patients After Allogeneic Hematopoietic Stem Cell Transplantation: A Retrospective Cohort Study.FLT3-ITD与DNMT3A R882突变相比是异基因造血干细胞移植后成人急性髓系白血病患者更有力的独立不良预后因素：一项回顾性队列研究
Turk J Haematol. 2018 Aug 3;35(3):158-167. doi: 10.4274/tjh.2018.0017. Epub 2018 May 22.
7
DNMT3A R882H mutation in acute myeloid leukemia cell line SET-2.
Leuk Res. 2020 Jan;88:106270. doi: 10.1016/j.leukres.2019.106270. Epub 2019 Nov 9.
8
DNMT3A mutations at R882 hotspot are only found in major clones of acute myeloid leukemia.仅在急性髓系白血病的主要克隆中发现R882热点处的DNMT3A突变。
Leuk Lymphoma. 2014 Mar;55(3):711-4. doi: 10.3109/10428194.2013.811580. Epub 2013 Jul 25.
9
DNMT3A mutations in acute myeloid leukemia: impact on low-risk patients with CEBPA mutations.急性髓系白血病中的DNMT3A突变：对伴有CEBPA突变的低风险患者的影响。
J Clin Oncol. 2011 Dec 1;29(34):4592-3; author reply 4593-4. doi: 10.1200/JCO.2011.38.2127. Epub 2011 Oct 31.
10
Acute myeloid leukemia with DNMT3A mutations.伴有DNMT3A基因突变的急性髓系白血病
Leuk Lymphoma. 2014 Sep;55(9):2002-12. doi: 10.3109/10428194.2013.869802. Epub 2014 Mar 7.
引用本文的文献
1
Targeting Calprotectin S100A8/A9 to Overcome AML Progression in DNMT3A-Mutant Cells.靶向钙卫蛋白S100A8/A9以克服DNMT3A突变细胞中的急性髓系白血病进展
Curr Med Sci. 2025 Apr 23. doi: 10.1007/s11596-025-00042-2.
2
R882 Mutations Confer Unique Clinicopathologic Features in MDS Including a High Risk of AML Transformation.R882突变在骨髓增生异常综合征中赋予独特的临床病理特征，包括急性髓系白血病转化的高风险。
Front Oncol. 2022 Feb 28;12:849376. doi: 10.3389/fonc.2022.849376. eCollection 2022.
3
DNMT3A Harboring Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks.DNMT3A 携带白血病相关突变可导致其对复制叉处的 DNA 损伤敏感。
Clin Cancer Res. 2022 Feb 15;28(4):756-769. doi: 10.1158/1078-0432.CCR-21-2863.
4
Myelodysplasia Syndrome, Clonal Hematopoiesis and Cardiovascular Disease.骨髓增生异常综合征、克隆性造血与心血管疾病
Cancers (Basel). 2021 Apr 19;13(8):1968. doi: 10.3390/cancers13081968.
5
Alterations to in Hematologic Malignancies.血液系统恶性肿瘤中的 改变。
Cancer Res. 2021 Jan 15;81(2):254-263. doi: 10.1158/0008-5472.CAN-20-3033. Epub 2020 Oct 21.
6
DNMT3A alterations associated with myeloid malignancies dictate differential responses to hypomethylating agents.与髓系恶性肿瘤相关的DNMT3A改变决定了对低甲基化药物的不同反应。
Leuk Res. 2020 Jul;94:106372. doi: 10.1016/j.leukres.2020.106372. Epub 2020 May 13.
7
Oncogenic Roles and Inhibitors of DNMT1, DNMT3A, and DNMT3B in Acute Myeloid Leukaemia.DNMT1、DNMT3A和DNMT3B在急性髓系白血病中的致癌作用及抑制剂
Biomark Insights. 2019 May 8;14:1177271919846454. doi: 10.1177/1177271919846454. eCollection 2019.
8
Clinical implications of somatic mutations in aplastic anemia and myelodysplastic syndrome in genomic age.基因组时代骨髓增生异常综合征和再生障碍性贫血体细胞突变的临床意义。
Hematology Am Soc Hematol Educ Program. 2017 Dec 8;2017(1):66-72. doi: 10.1182/asheducation-2017.1.66.
本文引用的文献
1
Dynamics of clonal evolution in myelodysplastic syndromes.骨髓增生异常综合征的克隆进化动力学
Nat Genet. 2017 Feb;49(2):204-212. doi: 10.1038/ng.3742. Epub 2016 Dec 19.
2
DNMT3A in haematological malignancies.血液系统恶性肿瘤中的DNA甲基转移酶3A（DNMT3A）
Nat Rev Cancer. 2015 Mar;15(3):152-65. doi: 10.1038/nrc3895. Epub 2015 Feb 19.
3
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence.从血液DNA序列推断克隆性造血与血癌风险。
N Engl J Med. 2014 Dec 25;371(26):2477-87. doi: 10.1056/NEJMoa1409405. Epub 2014 Nov 26.
4
Age-related clonal hematopoiesis associated with adverse outcomes.与不良预后相关的年龄相关性克隆性造血。
N Engl J Med. 2014 Dec 25;371(26):2488-98. doi: 10.1056/NEJMoa1408617. Epub 2014 Nov 26.
5
Age-related mutations associated with clonal hematopoietic expansion and malignancies.与克隆性造血扩张和恶性肿瘤相关的年龄相关突变。
Nat Med. 2014 Dec;20(12):1472-8. doi: 10.1038/nm.3733. Epub 2014 Oct 19.
6
The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers.R882H DNMT3A 突变与 AML 相关，通过阻断其形成活性四聚体的能力，显性抑制野生型 DNMT3A。
Cancer Cell. 2014 Apr 14;25(4):442-54. doi: 10.1016/j.ccr.2014.02.010. Epub 2014 Mar 20.
7
A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells.一种在 AML 中常见的 DNMT3A 突变在鼠胚胎干细胞中表现出显性负效应。
Blood. 2013 Dec 12;122(25):4086-9. doi: 10.1182/blood-2013-02-483487. Epub 2013 Oct 28.
8
Landmark analysis of DNMT3A mutations in hematological malignancies.血液系统恶性肿瘤中DNMT3A突变的标志性分析。
Leukemia. 2013 Jul;27(7):1573-8. doi: 10.1038/leu.2013.65. Epub 2013 Mar 1.
9
The role of mutations in epigenetic regulators in myeloid malignancies.基因突变在髓系恶性肿瘤中表观遗传学调控中的作用。
Nat Rev Cancer. 2012 Sep;12(9):599-612. doi: 10.1038/nrc3343. Epub 2012 Aug 17.
10
Mutations in DNA methyltransferase (DNMT3A) observed in acute myeloid leukemia patients disrupt processive methylation.在急性髓系白血病患者中观察到的 DNA 甲基转移酶（DNMT3A）突变会破坏连续性甲基化。
J Biol Chem. 2012 Sep 7;287(37):30941-51. doi: 10.1074/jbc.M112.366625. Epub 2012 Jun 21.
Zotero 插件