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DNMT3A alterations associated with myeloid malignancies dictate differential responses to hypomethylating agents.

作者信息

Casellas Román Heidi L, Venugopal Kartika, Feng Yang, Shabashvili Daniil E, Posada Luisa M, Li Jianping, Guryanova Olga A

机构信息

Department of Pharmacology & Therapeutics, University of Florida College of Medicine, Gainesville, FL, United States; Department of Pharmacology and Toxicology, University of Puerto Rico School of Medicine, Medical Sciences Campus, San Juan, PR, Puerto Rico.

Department of Pharmacology & Therapeutics, University of Florida College of Medicine, Gainesville, FL, United States.

出版信息

Leuk Res. 2020 Jul;94:106372. doi: 10.1016/j.leukres.2020.106372. Epub 2020 May 13.

DOI:10.1016/j.leukres.2020.106372
PMID:32445940
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7481860/
Abstract
摘要

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本文引用的文献

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Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes.TP53 等位基因状态对骨髓增生异常综合征的基因组稳定性、临床表现和预后的影响。
Nat Med. 2020 Oct;26(10):1549-1556. doi: 10.1038/s41591-020-1008-z. Epub 2020 Aug 3.
2
Distinct clinical and biological implications of various DNMT3A mutations in myeloid neoplasms.髓系肿瘤中各种DNMT3A突变的不同临床和生物学意义。
Leukemia. 2018 Feb;32(2):550-553. doi: 10.1038/leu.2017.295. Epub 2017 Sep 22.
3
Tracing the origins of relapse in acute myeloid leukaemia to stem cells.追溯急性髓系白血病复发的根源到干细胞。
Nature. 2017 Jul 6;547(7661):104-108. doi: 10.1038/nature22993. Epub 2017 Jun 28.
4
Hypomethylating Agents as a Therapy for AML.低甲基化剂作为急性髓系白血病的一种治疗方法。
Curr Hematol Malig Rep. 2017 Feb;12(1):1-10. doi: 10.1007/s11899-017-0363-4.
5
DNMT3A in Leukemia.白血病中的DNA甲基转移酶3A（DNMT3A）
Cold Spring Harb Perspect Med. 2017 Feb 1;7(2):a030320. doi: 10.1101/cshperspect.a030320.
6
DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling.DNMT3A突变通过受损的核小体重塑促进急性髓性白血病对蒽环类药物的耐药性。
Nat Med. 2016 Dec;22(12):1488-1495. doi: 10.1038/nm.4210. Epub 2016 Nov 14.
7
Targeting the cancer epigenome for therapy.针对癌症表观基因组进行治疗。
Nat Rev Genet. 2016 Sep 15;17(10):630-41. doi: 10.1038/nrg.2016.93.
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Mutational correlates of response to hypomethylating agent therapy in acute myeloid leukemia.急性髓系白血病中对去甲基化药物治疗反应的突变相关性
Haematologica. 2016 Nov;101(11):e457-e460. doi: 10.3324/haematol.2016.148999. Epub 2016 Jul 14.
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Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells.Dnmt3a调控造血干细胞和祖细胞的骨髓增殖及肝脏特异性扩增。
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Cancer Cell. 2014 Apr 14;25(4):442-54. doi: 10.1016/j.ccr.2014.02.010. Epub 2014 Mar 20.