Altwairgi Abdullah K, Raja Shanker, Manzoor Mohammed, Aldandan Sadeq, Alsaeed Eyad, Balbaid Ali, Alhussain Hussain, Orz Yassir, Lary Ahmed, Alsharm Abdullah A
Department of Medical Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh, Saudi Arabia.
Department of Medical Imaging, King Fahad Medical City, Riyadh, Saudi Arabia.
Int J Health Sci (Qassim). 2017 Jul-Sep;11(3):54-62.
The treatment recommendations provided in this manuscript are intended to serve as a knowledge base for clinicians and health personals involved in treating patients with high-grade malignant glioma. In newly diagnosed patients, complete resection or biopsy is required for histological characterization of the tumor, which in turn is essential to decide the treatment strategy. In patients with good or borderline performance score, radiotherapy (RT), and chemotherapy are the preferred management. In patients with poor performance score, RT with best possible supportive care is the mainstay of the management. All patients have to undergo brain magnetic resonance imaging procedure quarterly or half-yearly for 5 years and then on an annual basis. In patients with recurrent malignant glioma, wherever possible re-resection or re-irradiation or chemotherapy can be considered along with supportive and palliative care. High-grade malignant glioma should be managed in a multidisciplinary center with the best of the possible care that is available based on the evidence as discussed in this manuscript.
本手稿中提供的治疗建议旨在为参与治疗高级别恶性胶质瘤患者的临床医生和卫生人员提供一个知识库。对于新诊断的患者，需要进行完整切除或活检以对肿瘤进行组织学特征描述，这对于决定治疗策略至关重要。对于表现评分良好或临界的患者，放疗（RT）和化疗是首选的治疗方法。对于表现评分较差的患者，以最佳支持治疗的放疗是主要的治疗手段。所有患者在5年内必须每季度或半年进行一次脑磁共振成像检查，之后每年进行一次。对于复发性恶性胶质瘤患者，只要有可能，可考虑再次切除、再次放疗或化疗，同时给予支持和姑息治疗。高级别恶性胶质瘤应在多学科中心进行管理，并根据本手稿中讨论的证据提供尽可能最佳的护理。
