J Natl Compr Canc Netw. 2016 Jul;14(7):882-913. doi: 10.6004/jnccn.2016.0093.
Infectious diseases are important causes of morbidity and mortality in patients with cancer. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Prevention and Treatment of Cancer-Related Infections characterize the major pathogens to which patients with cancer are susceptible, with a focus on the prevention, diagnosis, and treatment of major common and opportunistic infections. This portion of the guidelines highlights the sections on antifungal and antiviral prophylaxis. Antifungal and antiviral prophylaxis recommendations have expanded over the past few years. New agents for the treatment of fungal infections and incorporation of therapeutic drug monitoring are presented. Antiviral prophylaxis for hepatitis B and management considerations for hepatitis C and HIV have been further developed.
传染病是癌症患者发病率和死亡率的重要原因。美国国家综合癌症网络(NCCN)肿瘤临床实践指南(NCCN 指南)针对与癌症相关感染的预防和治疗,对癌症患者易感染的主要病原体进行了描述,重点是预防、诊断和治疗常见和机会性感染。本指南的这一部分突出了抗真菌和抗病毒预防部分。近年来,抗真菌和抗病毒预防建议有所扩展。本文介绍了治疗真菌感染的新药物和治疗药物监测的应用。乙型肝炎的抗病毒预防以及丙型肝炎和 HIV 的管理注意事项也得到了进一步发展。