促肾上腺皮质激素释放激素（CRH）在亨廷顿舞蹈症患者的基底神经节中含量降低。

Corticotropin-releasing hormone (CRH) is decreased in the basal ganglia in Huntington's disease.

作者信息

De Souza E B, Whitehouse P J, Folstein S E, Price D L, Vale W W

机构信息

Neuroscience Branch, National Institute on Drug Abuse, Baltimore, MD 21224.

出版信息

Brain Res. 1987 Dec 29;437(2):355-9. doi: 10.1016/0006-8993(87)91651-9.

DOI:10.1016/0006-8993(87)91651-9

PMID:2893655

Abstract

Corticotropin-releasing hormone-like immunoreactivity (CRH-IR) was measured in control and Huntington's disease brain tissues obtained postmortem. The concentration of CRH-IR was markedly decreased in the caudate/putamen in Huntington's disease; the concentration of somatostatin-like immunoreactivity measured in the same extracts was significantly increased in the caudate/putamen in Huntington's disease compared with the control group. In contrast to previously reported decreases in CRH-IR in the cerebral cortex in Alzheimer's disease, Parkinson's disease and progressive supranuclear palsy, no significant differences were observed in the concentrations of CRH-IR between controls and Huntington's disease in frontal, parietal, temporal, occipital and cingulate cortex and in globus pallidus.

摘要

在死后获取的对照和亨廷顿病脑组织中测量促肾上腺皮质激素释放激素样免疫反应性（CRH-IR）。亨廷顿病患者尾状核/壳核中的CRH-IR浓度显著降低；与对照组相比，在相同提取物中测量的亨廷顿病患者尾状核/壳核中生长抑素样免疫反应性浓度显著升高。与先前报道的阿尔茨海默病、帕金森病和进行性核上性麻痹患者大脑皮质中CRH-IR降低相反，在额叶、顶叶、颞叶、枕叶和扣带回皮质以及苍白球中，对照组和亨廷顿病患者之间的CRH-IR浓度未观察到显著差异。