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在生命的最后阶段,治疗目标与住院和医院死亡率有何关联?对荷兰五种癌症患者的死亡率回溯研究。

How do treatment aims in the last phase of life relate to hospitalizations and hospital mortality? A mortality follow-back study of Dutch patients with five types of cancer.

机构信息

Department of Public and Occupational Health, Amsterdam Public Health research institute, Expertise Center for Palliative Care, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands.

NIVEL, Netherlands Institute of Health Services Research, Utrecht, The Netherlands.

出版信息

Support Care Cancer. 2018 Mar;26(3):777-786. doi: 10.1007/s00520-017-3889-z. Epub 2017 Sep 22.

Abstract

PURPOSE

The purpose of this study is to describe and compare the relation between treatment aims, hospitalizations, and hospital mortality for Dutch patients who died from lung, colorectal, breast, prostate, or pancreatic cancer.

METHODS

A mortality follow-back study was conducted within a sentinel network of Dutch general practitioners (GPs), who recorded the end-of-life care of 691 patients who died from one of the abovementioned cancer types between 2009 and 2015. Differences in care by type of cancer were analyzed using multilevel analyses to control for clustering within general practices.

RESULTS

Among all cancer types, patients with prostate cancer most often and patients with pancreatic cancer least often had a palliative treatment aim a month before death (95% resp. 84%). Prostate cancer patients were also least often admitted to hospital in the last month of life (18.5%) and least often died there (3.1%), whereas lung cancer patients were at the other end of the spectrum with 41.8% of them being admitted to hospital and 22.6% dying in hospital. Having a palliative treatment aim and being older were significantly associated with less hospital admissions, and having a palliative treatment aim, having prostate cancer, and dying in a more recent year were significantly associated with less hospital deaths.

CONCLUSION

There is large variation between patients with different cancer types with regard to treatment aims, hospital admissions, and hospital deaths. The results highlight the need for early initiation of GP palliative care to support patients from all cancer types to stay at the place they prefer as long as possible.

摘要

目的

本研究旨在描述和比较荷兰死于肺癌、结直肠癌、乳腺癌、前列腺癌或胰腺癌的患者的治疗目标、住院情况和住院死亡率之间的关系。

方法

在荷兰全科医生(GP)的监测网络中进行了一项死亡率回溯研究,该网络记录了 2009 年至 2015 年间死于上述癌症类型之一的 691 名患者的临终关怀情况。使用多水平分析来控制全科医生实践中的聚类,分析不同癌症类型的护理差异。

结果

在所有癌症类型中,前列腺癌患者在死亡前一个月最常(95%)和胰腺癌患者最不常(84%)有姑息治疗目标。前列腺癌患者在生命的最后一个月住院的比例也最低(18.5%),在医院死亡的比例也最低(3.1%),而肺癌患者则处于相反的极端,有 41.8%的患者住院,22.6%的患者在医院死亡。姑息治疗目标和年龄较大与住院次数减少显著相关,而姑息治疗目标、前列腺癌和在更近的年份死亡与住院死亡次数减少显著相关。

结论

不同癌症类型的患者在治疗目标、住院情况和住院死亡方面存在很大差异。研究结果强调了早期启动全科医生姑息治疗的必要性,以支持所有癌症类型的患者尽可能长时间地留在他们喜欢的地方。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2ae/5785603/6b25f2ff0b9d/520_2017_3889_Fig1_HTML.jpg

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