School of Psychology, Brain and Mind Centre, University of Sydney, Camperdown, Sydney, NSW, Australia.
School of Psychiatry, University of New South Wales, Black Dog Institute, Randwick, Sydney, NSW, Australia.
Eur Child Adolesc Psychiatry. 2018 Jul;27(7):823-837. doi: 10.1007/s00787-017-1050-7. Epub 2017 Sep 21.
This meta-analysis aimed to update existing data on the comparison of prevalence rates of psychopathology primarily among offspring with at least one parent with bipolar disorder (BD) and offspring of parents without psychiatric illness. Seventeen studies were derived from a systematic search of PsychInfo, Medline, Scopus and Embase. Inclusion criteria were use of a control offspring group, standardized diagnostic procedures and reporting of clear frequency data. Risk of psychopathology was estimated by aggregating frequency data from selected studies. Compared to control offspring, high-risk BD offspring are nine times more likely to have a bipolar-type disorder, almost two and a half times more likely to develop a non-BD affective disorder and over two times more likely to develop at least one anxiety disorder. High-risk offspring also showed a significant increased risk of other non-mood psychopathology such as attention deficit hyperactivity disorder (ADHD), any type of behavioral disorder and substance use disorder (SUDs). Risk of developing a broad range of affective and non-affective psychopathology is significantly higher in high-risk BD offspring. Identifying clinical presentations of this genetically high-risk cohort is important in establishing appropriate preventative treatment.
本荟萃分析旨在更新关于至少有一位父母患有双相情感障碍（BD）和父母无精神疾病的后代的精神病理学患病率比较的现有数据。从 PsychInfo、Medline、Scopus 和 Embase 进行系统检索得到了 17 项研究。纳入标准为使用对照后代群体、标准化诊断程序和报告明确的频率数据。通过汇总选定研究的频率数据来估计精神病理学的风险。与对照后代相比，高风险 BD 后代患双相情感障碍的可能性高出九倍，患非 BD 情感障碍的可能性高出近两倍半，患至少一种焦虑障碍的可能性高出两倍以上。高危后代还表现出其他非情感性精神病理学的显著增加风险，如注意缺陷多动障碍（ADHD）、任何类型的行为障碍和物质使用障碍（SUDs）。高风险 BD 后代患广泛的情感和非情感性精神病理学的风险显著更高。确定这一遗传高风险群体的临床表现对于确定适当的预防治疗非常重要。
