通过区域选择性 Heck 偶联反应从芳基乙烯基 MIDA 硼酸酯中获得三芳基乙烯单元的模块化方法。
Modular Access to Triarylethylene Units from Arylvinyl MIDA Boronates Using a Regioselective Heck Coupling.
机构信息
Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation, (CBI)-UMR 8231 ESPCI Paris/CNRS/PSL* Research University , 10 rue Vauquelin, Paris 75231 Cedex 05, France.
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University , 21 Nanyang Link, Singapore 637371.
出版信息
Org Lett. 2017 Oct 6;19(19):5046-5049. doi: 10.1021/acs.orglett.7b02218. Epub 2017 Sep 22.
A palladium-catalyzed, silver-mediated Heck coupling between arylvinyl MIDA boronate esters and aryl iodides is disclosed. The reaction provides an efficient and modular access to a range of 1,1-diaryl alkenyl MIDA boronates that can be easily transformed into triarylethylene compounds through a Suzuki coupling.
本文公开了一种钯催化、银介导的芳基乙烯基 MIDA 硼酸酯与芳基碘化物的 Heck 偶联反应。该反应为一系列 1,1-二芳基烯基 MIDA 硼酸酯提供了高效且模块化的合成途径，这些硼酸酯可以通过 Suzuki 偶联很容易转化为三芳基乙烯化合物。
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