动态循环相互作用：为巨噬细胞搭建三维舞台
Dynamic Looping Interactions: Setting the 3D Stage for the Macrophage.
作者信息
Rege Mayuri, Phillips-Cremins Jennifer E
机构信息
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Mol Cell. 2017 Sep 21;67(6):901-903. doi: 10.1016/j.molcel.2017.09.011.
Abstract
The mechanisms by which 3D chromatin looping interactions mediate cell type-specific gene expression are an active area of investigation. In this issue of Molecular Cell, Phanstiel et al. (2017) annotate five classes of loops during macrophage development and predict candidate factors involved in their regulation.
摘要
3D染色质环化相互作用介导细胞类型特异性基因表达的机制是一个活跃的研究领域。在本期《分子细胞》中，范斯蒂尔等人（2017年）对巨噬细胞发育过程中的五类环化进行了注释，并预测了参与其调控的候选因子。
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本文引用的文献
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Mol Cell. 2017 Sep 21;67(6):1037-1048.e6. doi: 10.1016/j.molcel.2017.08.006. Epub 2017 Sep 7.
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Lineage-specific dynamic and pre-established enhancer-promoter contacts cooperate in terminal differentiation.谱系特异性动态和预先建立的增强子-启动子相互作用在终末分化中协同作用。
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YY1 and CTCF orchestrate a 3D chromatin looping switch during early neural lineage commitment.YY1和CTCF在早期神经谱系定向分化过程中协调3D染色质环化开关。
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