Rege Mayuri, Phillips-Cremins Jennifer E
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Mol Cell. 2017 Sep 21;67(6):901-903. doi: 10.1016/j.molcel.2017.09.011.
The mechanisms by which 3D chromatin looping interactions mediate cell type-specific gene expression are an active area of investigation. In this issue of Molecular Cell, Phanstiel et al. (2017) annotate five classes of loops during macrophage development and predict candidate factors involved in their regulation.
3D染色质环化相互作用介导细胞类型特异性基因表达的机制是一个活跃的研究领域。在本期《分子细胞》中,范斯蒂尔等人(2017年)对巨噬细胞发育过程中的五类环化进行了注释,并预测了参与其调控的候选因子。