• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

非编码RNA与癌细胞和癌症干细胞中河马信号通路的相互作用。

Interaction of noncoding RNAs with hippo signaling pathway in cancer cells and cancer stem cells.

作者信息

Abedimanesh Saba, Safaralizadeh Reza, Jahanafrooz Zohreh, Najafi Souzan, Amini Mohammad, Nazarloo Shabnam Soltani, Bahojb Mahdavi Seyedeh Zahra, Baradaran Behzad, Jebelli Asiyeh, Mokhtarzadeh Amir Ali

机构信息

Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.

Department of Biology, Faculty of Sciences, University of Maragheh, Maragheh, Iran.

出版信息

Noncoding RNA Res. 2024 Jun 6;9(4):1292-1307. doi: 10.1016/j.ncrna.2024.06.006. eCollection 2024 Dec.

DOI:10.1016/j.ncrna.2024.06.006
PMID:39045083
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11263728/
Abstract

The Hippo signaling pathway has a regulatory function in the organogenesis process and cellular homeostasis, switching the cascade reactions of crucial kinases acts to turn off/on the Hippo pathway, altering the downstream gene expression and thereby regulating proliferation, apoptosis, or stemness. Disruption of this pathway can lead to the occurrence of various disorders and different types of cancer. Recent findings highlight the importance of ncRNAs, such as microRNA, circular RNA, and lncRNAs, in modulating the Hippo pathway. Defects in ncRNAs can disrupt Hippo pathway balance, increasing tumor cells, tumorigenesis, and chemotherapeutic resistance. This review summarizes ncRNAs' inhibitory or stimulatory role in - Hippo pathway regulation in cancer and stem cells. Identifying the relation between ncRNAs and the components of this pathway could pave the way for developing new biomarkers in the treatment and diagnosis of cancers.

摘要

河马信号通路在器官发生过程和细胞内稳态中具有调节功能，关键激酶的级联反应开关作用于关闭/开启河马通路，改变下游基因表达，从而调节细胞增殖、凋亡或干性。该通路的破坏可导致各种疾病和不同类型癌症的发生。最近的研究结果突出了非编码RNA（如微小RNA、环状RNA和长链非编码RNA）在调节河马通路中的重要性。非编码RNA的缺陷会破坏河马通路平衡，增加肿瘤细胞、肿瘤发生和化疗耐药性。本综述总结了非编码RNA在癌症和干细胞中对河马通路调节的抑制或刺激作用。确定非编码RNA与该通路各成分之间的关系可为开发癌症治疗和诊断中的新生物标志物铺平道路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a92c/11263728/1673111c149f/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a92c/11263728/a39a50cba3d3/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a92c/11263728/9c8ee95bebc1/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a92c/11263728/c62c8a9fbbb7/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a92c/11263728/efe034320d6c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a92c/11263728/746da1ad80e1/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a92c/11263728/b3ab5256ec7f/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a92c/11263728/1673111c149f/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a92c/11263728/a39a50cba3d3/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a92c/11263728/9c8ee95bebc1/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a92c/11263728/c62c8a9fbbb7/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a92c/11263728/efe034320d6c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a92c/11263728/746da1ad80e1/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a92c/11263728/b3ab5256ec7f/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a92c/11263728/1673111c149f/gr7.jpg

相似文献

1
Interaction of noncoding RNAs with hippo signaling pathway in cancer cells and cancer stem cells.非编码RNA与癌细胞和癌症干细胞中河马信号通路的相互作用。
Noncoding RNA Res. 2024 Jun 6;9(4):1292-1307. doi: 10.1016/j.ncrna.2024.06.006. eCollection 2024 Dec.
2
Interaction of non-coding RNAs and Hippo signaling: Implications for tumorigenesis.非编码 RNA 与 Hippo 信号通路的相互作用：对肿瘤发生的影响。
Cancer Lett. 2020 Nov 28;493:207-216. doi: 10.1016/j.canlet.2020.08.012. Epub 2020 Aug 19.
3
Role of Hedgehog and Hippo signaling pathways in cancer: A special focus on non-coding RNAs.Hedgehog 和 Hippo 信号通路在癌症中的作用：特别关注非编码 RNA。
Pharmacol Res. 2022 Dec;186:106523. doi: 10.1016/j.phrs.2022.106523. Epub 2022 Oct 28.
4
Circular RNAs modulate Hippo-YAP signaling: functional mechanisms in cancer.环状 RNAs 调控 Hippo-YAP 信号通路：癌症中的功能机制。
Theranostics. 2022 May 16;12(9):4269-4287. doi: 10.7150/thno.71708. eCollection 2022.
5
Non-coding RNAs as regulators of the Hippo pathway in cardiac development and cardiovascular disease.非编码RNA作为心脏发育和心血管疾病中Hippo信号通路的调节因子
Front Pharmacol. 2024 Apr 18;15:1348280. doi: 10.3389/fphar.2024.1348280. eCollection 2024.
6
Deciphering the functional landscape and therapeutic implications of noncoding RNAs in the TGF-β signaling pathway in colorectal cancer: A comprehensive review.解读非编码RNA在结直肠癌转化生长因子-β信号通路中的功能格局及治疗意义：一项综述
Pathol Res Pract. 2024 Mar;255:155158. doi: 10.1016/j.prp.2024.155158. Epub 2024 Jan 22.
7
Noncoding RNAs in DNA Damage Response: Opportunities for Cancer Therapeutics.DNA损伤反应中的非编码RNA：癌症治疗的机遇
Methods Mol Biol. 2018;1699:3-21. doi: 10.1007/978-1-4939-7435-1_1.
8
Advances in Understanding the LncRNA-Mediated Regulation of the Hippo Pathway in Cancer.癌症中长链非编码RNA介导的Hippo信号通路调控机制的研究进展
Onco Targets Ther. 2021 Apr 7;14:2397-2415. doi: 10.2147/OTT.S283157. eCollection 2021.
9
The emerging role of noncoding RNAs in the PI3K/AKT/mTOR signalling pathway in breast cancer.非编码RNA在乳腺癌PI3K/AKT/mTOR信号通路中的新兴作用
Pathol Res Pract. 2024 Mar;255:155180. doi: 10.1016/j.prp.2024.155180. Epub 2024 Jan 30.
10
The interplay between m6A modification and non-coding RNA in cancer stemness modulation: mechanisms, signaling pathways, and clinical implications.m6A 修饰与非编码 RNA 在癌症干性调控中的相互作用：机制、信号通路及临床意义。
Int J Biol Sci. 2021 Jun 26;17(11):2718-2736. doi: 10.7150/ijbs.60641. eCollection 2021.

引用本文的文献

1
LncRNA regulation in ischemic stroke and their application prospects.缺血性中风中的长链非编码RNA调控及其应用前景。
Neural Regen Res. 2026 Mar 1;21(3):1058-1073. doi: 10.4103/NRR.NRR-D-24-00924. Epub 2025 Mar 25.

本文引用的文献

1
Circular RNA hsa_circ_0051246 acts as a microRNA-375 sponge to promote the progression of gastric cancer stem cells YAP1.环状 RNA hsa_circ_0051246 通过海绵吸附 microRNA-375 促进胃癌干细胞 YAP1 的进展。
PeerJ. 2023 Nov 30;11:e16523. doi: 10.7717/peerj.16523. eCollection 2023.
2
Template-Independent Poly(A)-Tail Decay and RNASEL as Potential Cellular Biomarkers for Prostate Cancer Development.不依赖模板的聚腺苷酸尾衰变及RNASEL作为前列腺癌发生发展的潜在细胞生物标志物
Cancers (Basel). 2022 Apr 29;14(9):2239. doi: 10.3390/cancers14092239.
3
Therapeutic approaches for the treatment of head and neck squamous cell carcinoma-An update on clinical trials.
头颈部鳞状细胞癌的治疗方法——临床试验的最新进展
Transl Oncol. 2022 Jul;21:101426. doi: 10.1016/j.tranon.2022.101426. Epub 2022 Apr 20.
4
Roles and mechanisms of miR-195-5p in human solid cancers.miR-195-5p 在人类实体瘤中的作用和机制。
Biomed Pharmacother. 2022 Jun;150:112885. doi: 10.1016/j.biopha.2022.112885. Epub 2022 Apr 19.
5
Diagnostic and prognostic significance of long noncoding RNA LINC00173 in patients with melanoma.长链非编码 RNA LINC00173 在黑色素瘤患者中的诊断和预后意义。
Rev Assoc Med Bras (1992). 2022 Feb;68(2):170-175. doi: 10.1590/1806-9282.20210822.
6
Modulation of Hippo signaling by Mnat9 N-acetyltransferase for normal growth and tumorigenesis in Drosophila.Mnat9 N- 乙酰基转移酶对 Hippo 信号通路的调控在果蝇正常生长和肿瘤发生中的作用。
Cell Death Dis. 2022 Feb 2;13(2):101. doi: 10.1038/s41419-022-04532-2.
7
Long non-coding RNAs in gastrointestinal cancers: Implications for protein phosphorylation.长非编码 RNA 在胃肠道癌症中的作用：对蛋白质磷酸化的影响。
Biochem Pharmacol. 2022 Mar;197:114907. doi: 10.1016/j.bcp.2022.114907. Epub 2022 Jan 7.
8
LncRNA DLGAP1-AS2 overexpression associates with gastric tumorigenesis: a promising diagnostic and therapeutic target.长链非编码 RNA DLGAP1-AS2 的过表达与胃癌发生相关：一个有前途的诊断和治疗靶点。
Mol Biol Rep. 2022 Jul;49(7):6817-6826. doi: 10.1007/s11033-021-07038-w. Epub 2022 Jan 4.
9
LncRNA SFTA1P mediates positive feedback regulation of the Hippo-YAP/TAZ signaling pathway in non-small cell lung cancer.长链非编码RNA SFTA1P介导非小细胞肺癌中Hippo-YAP/TAZ信号通路的正反馈调节。
Cell Death Discov. 2021 Nov 29;7(1):369. doi: 10.1038/s41420-021-00761-0.
10
Notch Signaling and MicroRNA: The Dynamic Duo Steering Between Neurogenesis and Glioblastomas.Notch 信号通路与 microRNA：神经发生与胶质母细胞瘤之间的动态双重调控。
Cell Mol Biol (Noisy-le-grand). 2021 Aug 15;67(2):33-43. doi: 10.14715/cmb/2021.67.2.6.