Bae Sun Hyun, Jang Won Il, Park Hee Chul
Department of Radiation Oncology, Soonchunhyang University College of Medicine, Bucheon, Korea.
Department of Radiation Oncology, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
Oncotarget. 2017 Jul 13;8(35):59965-59976. doi: 10.18632/oncotarget.19219. eCollection 2017 Aug 29.
Since the introduction of 3-dimensional conformal radiotherapy (3DCRT), new radiotherapy techniques have expanded the indication of radiotherapy for the treatment of hepatocellular carcinoma (HCC), from the hitherto palliative to a now curative-intent purpose. Intensity-modulated radiotherapy (IMRT), currently the most advanced radiotherapy technique, is considered an attractive option for the treatment of HCC, and is more widely applied because it can deliver a higher dose to the tumor than 3DCRT while sparing surrounding normal organs. However, the advantages and potential disadvantages of IMRT for treating HCC have not been fully established. This article deals with three different IMRT techniques, including static IMRT and volumetric modulated arc therapy using conventional multileaf collimator (MLC) mounted linear accelerators, and helical IMRT using binary MLC mounted helical tomotherapy machine. We review dosimetric and clinical studies for these IMRT techniques for the treatment of HCC.
自从三维适形放疗（3DCRT）问世以来，新的放疗技术已将肝细胞癌（HCC）放疗的适应证从以往的姑息性治疗扩展到目前的根治性治疗目的。调强放疗（IMRT）是目前最先进的放疗技术，被认为是治疗HCC的一个有吸引力的选择，并且因其能比3DCRT向肿瘤输送更高剂量的同时保护周围正常器官而得到更广泛的应用。然而，IMRT治疗HCC的优势和潜在劣势尚未完全明确。本文探讨三种不同的IMRT技术，包括使用传统多叶准直器（MLC）的静态IMRT和容积调强弧形放疗，以及使用二元MLC的螺旋断层放疗机进行的螺旋IMRT。我们回顾了这些IMRT技术治疗HCC的剂量学和临床研究。
