通过缝隙预见肾小球疾病的未来：miR-NPNT 轴。

Foreseeing the future of glomerular disease through slits: miR-NPNT axis.

机构信息

Division of CKD Pathophysiology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.

Division of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.

出版信息

Kidney Int. 2017 Oct;92(4):782-784. doi: 10.1016/j.kint.2017.04.036.

DOI:10.1016/j.kint.2017.04.036

PMID:28938947

Abstract

Podocyte biology is an important key factor for the maintenance of glomerular function and structure. Nephronectin is a podocyte-derived extracellular matrix protein in the glomerular basement membrane. Suppression of nephronectin expression by microRNA-378a-3p significantly induced proteinuria due to loss of integrity of the glomerular filtration barrier in zebrafish and mice, demonstrating the relevance of the microRNA-nephronectin axis in regulation of the podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier.

摘要

足细胞生物学是维持肾小球功能和结构的重要关键因素。纤连蛋白是肾小球基底膜中足细胞衍生的细胞外基质蛋白。miR-378a-3p 对纤连蛋白表达的抑制作用显著诱导了斑马鱼和小鼠的蛋白尿，这是由于肾小球滤过屏障完整性的丧失，表明 microRNA-纤连蛋白轴在调节足细胞-肾小球基底膜相互作用和肾小球滤过屏障完整性方面的相关性。