Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA.
Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA.
Kidney Int. 2017 Oct;92(4):790-793. doi: 10.1016/j.kint.2017.05.025.
Complement activation probably contributes to glomerular inflammation and damage in IgA nephropathy. In this issue, 2 groups report that levels of factor H-related protein 1 are elevated in patients with IgA nephropathy and correlate with disease progression. These studies provide new evidence that the complement cascade is important to the pathogenesis of this disease. These results also suggest that factor H-related protein 1 levels may be useful for identifying those patients at high risk of disease progression.
补体激活可能导致 IgA 肾病的肾小球炎症和损伤。本期杂志中，两组研究人员报道 IgA 肾病患者的因子 H 相关蛋白 1 水平升高，且与疾病进展相关。这些研究为补体级联反应在该病发病机制中的重要性提供了新证据。这些结果还提示因子 H 相关蛋白 1 水平可能有助于识别那些疾病进展风险较高的患者。
