Division of Nephrology and Immunology, RWTH University of Aachen, Aachen, Germany.
Department of Nephrology, University Medical Center Leiden and University Medical Center Groningen, Groningen, The Netherlands.
Kidney Int. 2018 Jul;94(1):16-18. doi: 10.1016/j.kint.2018.03.009.
Glomerular complement deposition is common in IgA nephropathy, and recent genome-wide association studies point to a role of complement factor H and complement factor H-related proteins in disease susceptibility. A number of recent studies have now documented elevated levels of some factor H-related proteins in IgA nephropathy, which might contribute to enhanced complement activation.
肾小球补体沉积在 IgA 肾病中很常见，最近的全基因组关联研究表明补体因子 H 和补体因子 H 相关蛋白在疾病易感性中起作用。最近的一些研究已经记录了 IgA 肾病中某些补体因子 H 相关蛋白水平的升高，这可能有助于增强补体激活。
