口腔鳞状细胞癌的当前小鼠模型：遗传和化学诱导模型。
Current mouse models of oral squamous cell carcinoma: Genetic and chemically induced models.
机构信息
Department of Tumor Pathology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan; Department of Oral Maxillofacial Surgery, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan.
Department of Tumor Pathology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan.
出版信息
Oral Oncol. 2017 Oct;73:16-20. doi: 10.1016/j.oraloncology.2017.07.028.
Oral squamous cell carcinoma (OSCC) patients have a low 5-year survival rate and poor prognosis. To improve survival and prognosis, the causes and processes involved in lesion development should be evaluated. For this purpose, the use of OSCC mouse models, such as chemically induced mouse models, genetically modified mouse models, and transplanted (xenograft) models, is crucial. These OSCC models exhibit both advantages and disadvantages when studying OSCC development and progression. Until a model resembling human OSCC is developed, both the advantages and disadvantages of each model should be carefully considered. In this review, we discuss OSCC mouse models and their use in cancer research worldwide.
口腔鳞状细胞癌（OSCC）患者的 5 年生存率和预后较差。为了提高生存率和预后，应评估病变发展涉及的原因和过程。为此，使用 OSCC 小鼠模型，如化学诱导的小鼠模型、基因修饰的小鼠模型和移植（异种移植）模型至关重要。这些 OSCC 模型在研究 OSCC 的发展和进展时既有优点也有缺点。在开发出类似于人类 OSCC 的模型之前，应仔细考虑每种模型的优缺点。在这篇综述中，我们讨论了 OSCC 小鼠模型及其在全球癌症研究中的应用。
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