Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, University of Jordan, Amman, Jordan.
Department of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Applied Science Private University, Amman, Jordan.
Sci Rep. 2017 Sep 22;7(1):12210. doi: 10.1038/s41598-017-12431-2.
Surgical site infections (SSIs) following caesarean surgeries are common. The present study aimed to evaluate the frequency of SSIs following caesareans at Jordan University Hospital during the 30 postoperative days and to identify factors associated with increased SSIs risk. Data regarding the occurrence of SSIs were collected both prospectively via follow-up phone calls and retrospectively via reviewing wound culture results and clinical notes. SSI cases were subsequently determined utilizing predefined criteria. Data relating to possible risk factors of SSIs were collected from patient interviews and hospital records. Risk factors for SSIs were identified via logistic regression. A high rate of SSIs (14.4%) was detected; implicated factors included body mass index ≥36 kg/m prior to pregnancy odds ratio (OR) 3.8, 95% confidence interval (95% CI) 1.6-9.4, hospital stay longer than 3.5 days OR 2.3, 95% CI 1.4-3.6, having the operation at a gestational age greater than 40 weeks OR 2.2, 95% CI 1.3-3.9. Receiving a higher weight-adjusted dose of the prophylactic antibiotic cefazolin was associated with lower SSIs risk OR 0.967, 95% CI 0.94-0.99.In conclusion, a high rate of SSIs following caesareans was detected, and modifiable risk factors of SSIs should be incorporated into targeted policies aiming to reduce the rate of SSIs.
剖宫产术后手术部位感染(SSI)较为常见。本研究旨在评估 30 天内约旦大学医院剖宫产术后 SSI 的发生率,并确定与 SSI 风险增加相关的因素。通过前瞻性电话随访和回顾性查看伤口培养结果和临床记录收集 SSI 发生数据。随后利用预设标准确定 SSI 病例。从患者访谈和医院记录中收集与 SSI 相关的潜在危险因素数据。通过逻辑回归识别 SSI 的危险因素。检测到 SSI 发生率较高(14.4%);相关因素包括:孕前 BMI≥36kg/m2(优势比[OR]3.8,95%置信区间[95%CI]1.6-9.4)、住院时间超过 3.5 天(OR 2.3,95%CI 1.4-3.6)、手术时孕周大于 40 周(OR 2.2,95%CI 1.3-3.9)。接受更高的头孢唑啉预防抗生素剂量调整体重后,SSI 风险降低(OR 0.967,95%CI 0.94-0.99)。结论:剖宫产术后 SSI 发生率较高,应将 SSI 的可改变危险因素纳入旨在降低 SSI 发生率的针对性政策中。