Department of Psychology, University of Konstanz, Konstanz, Germany.
Department of Psychology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California, USA.
Psychophysiology. 2018 Apr;55(4). doi: 10.1111/psyp.13006. Epub 2017 Sep 21.
The auditory P50/M50 ERP/event-related field is subject to sensory gating, with partial suppression of the amplitude of the second of two (S1 and S2) clicks presented 500 ms apart. Schizophrenia patients have less gating, although quantification methods and associated effect sizes vary across studies using first-admission and/or using chronic patients. The present study evaluated the impact of several methods of quantifying gating in first-admission (FA) and chronic (CHR) schizophrenia patients and in healthy controls (HC). Magnetoencephalogram was measured in 35 FA, 58 CHR, and 28 HC during a paired-click protocol. Sensory gating was quantified on sensor and source levels as a ratio (S2/S1) and as a S1-minus-S2 difference, with M50 amplitude scored relative to baseline and relative to M100 and to M40. Independent of quantification method, patients showed less sensory gating than HC, with medium-to-large effect sizes, without differences between FA and CHR. Results indicate that the frequently reported sensory gating deficit in schizophrenia is robust to variations in quantification methods and stage of disorder.
听觉 P50/M50 ERP/事件相关磁场是受感觉门控影响的，两个相隔 500 毫秒的（S1 和 S2）相继点击的第二个（S2）的振幅会被部分抑制。精神分裂症患者的门控作用较小，尽管使用首次入院和/或慢性患者的研究中，量化方法和相关效应大小有所不同。本研究评估了几种量化首次入院（FA）和慢性（CHR）精神分裂症患者以及健康对照（HC）中门控的方法的影响。在配对点击方案中，对 35 名 FA、58 名 CHR 和 28 名 HC 进行了脑磁图测量。在传感器和源水平上，将感觉门控量化为比率（S2/S1）和 S1 减去 S2 的差值，M50 振幅相对于基线、M100 和 M40 进行评分。无论量化方法如何，患者的感觉门控均低于 HC，具有中到大的效应大小，FA 和 CHR 之间无差异。结果表明，精神分裂症中经常报道的感觉门控缺陷对量化方法和疾病阶段的变化具有稳健性。
