一种生长抑制性肝肽的纯化与特性分析。初步报告。
Purification and characterization of a growth inhibitory hepatic peptide. A preliminary note.
作者信息
Paulsen J E, Reichelt K L, Petersen A K
机构信息
Institute of Pathology, Rikshospitalet, Oslo, Norway.
出版信息
Virchows Arch B Cell Pathol Incl Mol Pathol. 1987;54(3):152-4. doi: 10.1007/BF02899207.
PMID:2894089
Abstract
A pentapeptide isolated from normal mouse liver seems to inhibit DNA synthesis (3H-thymidine incorporation into liver DNA and labeling indices) and the mitotic rate (G2-M cell flux) in regenerating mouse liver. The inhibitor is somewhat similar to the growth inhibitory pentapeptides previously reported for granulocytes and epidermis. It is active at very low dose levels, showing a bell-shaped dose-response curve.
摘要
从正常小鼠肝脏中分离出的一种五肽似乎能抑制再生小鼠肝脏中的DNA合成（3H-胸腺嘧啶核苷掺入肝脏DNA及标记指数）和有丝分裂率（G2-M期细胞通量）。该抑制剂与先前报道的对粒细胞和表皮具有生长抑制作用的五肽有些相似。它在极低剂量水平下就具有活性，呈现出钟形剂量反应曲线。
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