Nasal high flow therapy and PtCO in stable COPD: A randomized controlled cross-over trial.

BACKGROUND AND OBJECTIVE

Hypercapnia is associated with worse clinical outcomes in exacerbations of COPD. The present study aimed to determine the effects of nasal high flow (NHF) therapy on transcutaneous partial pressure of carbon dioxide (PtCO ) in stable COPD patients.

METHODS

In a single-blind randomized controlled cross-over trial, 48 participants with COPD were allocated in random order to all of four 20 min interventions: NHF at 15 L/min, 30 L/min and 45 L/min or breathing room air with each intervention followed by a washout period of 15 min. The primary outcome measure was PtCO at 20 min, adjusted for baseline PtCO . Secondary outcomes included respiratory rate at 20 min, adjusted for baseline.

RESULTS

The mean (95% CI) change in PtCO at 20 min was -0.6 mm Hg (-1.1 to 0.0), P = 0.06; -1.3 mm Hg (-1.9 to 0.8), P < 0.001; and -2.4 mm Hg (-2.9 to -1.8), P < 0.001; for NHF at 15 L/min, 30 L/min and 45 L/min compared with room air, respectively. The mean (95% CI) change in respiratory rate at 20 min was -1.5 (-2.7 to -0.3), P = 0.02; -4.1 (-5.3 to -2.9), P < 0.001; and -4.3 (-5.5 to -3.1), P < 0.001; breaths per minute compared with room air, respectively.

CONCLUSION

NHF results in a small flow-dependent reduction in PtCO and respiratory rate in patients with stable COPD.