HMPA促进的二芳基甲烷和三芳基甲烷与鲁珀特-普拉卡什试剂的硅二氟甲基化反应
HMPA-Promoted Siladifluoromethylation of Di-, and Triarylmethanes with the Ruppert-Prakash Reagent.
作者信息
Ji Xinfei, Zhao Xianghu, Shi Hongyan, Cao Song
机构信息
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology (ECUST), Shanghai, 200237, P.R. China.
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, P.R. China.
出版信息
Chem Asian J. 2017 Nov 2;12(21):2794-2798. doi: 10.1002/asia.201701224. Epub 2017 Oct 9.
PMID:28940982
Abstract
A mild and efficientmethod for the synthesis of α-siladifluoromethylated di-, and triarylmethanes via the reaction of di-, and triarylmethanes with Ruppert-Prakash reagents, using LDA and HMPA at room temperature, was developed.
摘要
开发了一种温和高效的方法，通过二芳基甲烷和三芳基甲烷与鲁佩特-普拉卡什试剂反应，在室温下使用LDA和HMPA合成α-硅二氟甲基化二芳基甲烷和三芳基甲烷。
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