从中国实验用雪貂和养殖水貂中检测到戊型肝炎病毒。
Hepatitis E virus detected from Chinese laboratory ferrets and farmed mink.
机构信息
Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
School of Laboratory Medicine, Tianjin Medical University, Tianjin, China.
出版信息
Transbound Emerg Dis. 2018 Feb;65(1):e219-e223. doi: 10.1111/tbed.12720. Epub 2017 Sep 22.
A novel genotype of hepatitis E virus (HEV) has been discovered in ferrets and mink worldwide. However, the situation in China is unknown. Diverse HEV RNA belonging to HEV genotype C2 was detected in this study from 17.5% (18/103) of the laboratory ferrets and 1.9% (2/107) of farmed mink in China. Phylogenetic analysis showed that the ferret HEV strains clustered into three groups with known strains detected from the United States and the Netherlands. Attempted transmission of ferret HEV to two rabbits was not successful. This study confirmed that the C2 genotype of HEV is circulating in China and succeeded in infecting laboratory ferrets with this genotype of HEV. Further studies are required to determine whether the C2 genotype of HEV can infect humans.
一种新型的戊型肝炎病毒（HEV）基因型已在世界各地的雪貂和水貂中被发现。然而，中国的情况尚不清楚。本研究在中国的 17.5%（18/103）实验室雪貂和 1.9%（2/107）养殖水貂中检测到属于 HEV 基因型 C2 的多种 HEV RNA。系统进化分析表明，来自美国和荷兰的已知株的水貂 HEV 株分为三组。试图将水貂 HEV 传播给两只兔子没有成功。本研究证实，C2 基因型的 HEV 在中国流行，并成功地用这种基因型的 HEV 感染了实验用雪貂。需要进一步研究以确定 C2 基因型的 HEV 是否可以感染人类。
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