Wang Bo, Harms Dominik, Yang Xing-Lou, Bock C-Thomas
Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Division of Viral Gastroenteritis and Hepatitis Pathogens and Enteroviruses, Department of Infectious Diseases, Robert Koch Institute, 13353 Berlin, Germany.
Pathogens. 2020 Feb 25;9(3):154. doi: 10.3390/pathogens9030154.
Hepatitis E virus (HEV) is an emerging zoonotic pathogen that has received an increasing amount of attention from virologists, clinicians, veterinarians, and epidemiologists over the past decade. The host range and animal reservoirs of HEV are rapidly expanding and a plethora of emerging HEV variants have been recently identified, some of which have the potential for interspecies infection. In this review, the detection of genetically diverse HEV variants, classified into and presumably associated with the species C, currently comprising HEV genotypes C1 and C2, by either serological or molecular approach is summarized. The distribution, genomic variability, and evolution of C are analyzed. Moreover, the potential risk of cross-species infection and zoonotic transmission of C are discussed.
戊型肝炎病毒（HEV）是一种新出现的人畜共患病原体，在过去十年中受到了病毒学家、临床医生、兽医和流行病学家越来越多的关注。HEV的宿主范围和动物宿主正在迅速扩大，最近已鉴定出大量新出现的HEV变异株，其中一些具有种间感染的潜力。在这篇综述中，总结了通过血清学或分子方法检测遗传多样的HEV变异株，这些变异株被分类为并可能与目前包括HEV基因型C1和C2的C种相关。分析了C种的分布、基因组变异性和进化。此外，还讨论了C种跨物种感染和人畜共患病传播的潜在风险。
