Department of Neurology, University Medical Center Goettingen, Goettingen, Germany.
Department of Neurology, University of Duisburg-Essen Medical School, Essen, Germany.
Stem Cells Transl Med. 2017 Nov;6(11):2044-2052. doi: 10.1002/sctm.17-0081. Epub 2017 Sep 23.
Despite recent advances in stroke therapy, current therapeutic concepts are still limited. Thus, additional therapeutic strategies are in order. In this sense, the transplantation of stem cells has appeared to be an attractive adjuvant tool to help boost the endogenous regenerative capacities of the brain. Although transplantation of stem cells is known to induce beneficial outcome in (preclinical) stroke research, grafted cells do not replace lost tissue directly. Rather, these transplanted cells like neural progenitor cells or mesenchymal stem cells act in an indirect manner, among which the secretion of extracellular vesicles (EVs) appears to be one key factor. Indeed, the application of EVs in preclinical stroke studies suggests a therapeutic role, which appears to be noninferior in comparison to the transplantation of stem cells themselves. In this short review, we highlight some of the recent advances in the field of EVs as a therapeutic means to counter stroke. Stem Cells Translational Medicine 2017;6:2044-2052.
尽管中风治疗在最近取得了进展,但目前的治疗理念仍然有限。因此,需要额外的治疗策略。在这种情况下,干细胞移植似乎是一种有吸引力的辅助工具,可以帮助增强大脑的内源性再生能力。尽管干细胞移植已知在(临床前)中风研究中能产生有益的结果,但移植的细胞并不能直接替代丢失的组织。相反,这些移植的细胞,如神经祖细胞或间充质干细胞,以间接的方式起作用,其中细胞外囊泡(EVs)的分泌似乎是一个关键因素。事实上,EVs 在临床前中风研究中的应用表明了其治疗作用,与干细胞本身的移植相比,其效果似乎并不逊色。在这篇简短的综述中,我们强调了 EVs 作为中风治疗手段的一些最新进展。《干细胞转化医学》2017;6:2044-2052。