Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, India.
Department of Medical Devices, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, India.
Clin Pharmacol Ther. 2018 Jun;103(6):990-998. doi: 10.1002/cpt.927. Epub 2017 Dec 14.
Numerous preclinical studies have been carried out using mesenchymal stem cells (MSCs) therapy for ischemic stroke. The purpose of the present meta-analysis is to review the quality of preclinical studies. In all, 4,361 articles were identified, out of which 64 studies were included (excluding in vitro studies). The results were obtained across species, route, and time of administration, immunogenicity, and doses. The median quality score 4.90/10, confidence interval 95%, and large effect size were observed, which strongly supports the translation potential of MSC therapy for ischemic stroke.
已经进行了许多使用间充质干细胞（MSCs）治疗缺血性中风的临床前研究。本荟萃分析的目的是回顾临床前研究的质量。总共确定了 4361 篇文章，其中包括 64 项研究（不包括体外研究）。结果涉及物种、给药途径和时间、免疫原性和剂量。中位数质量评分为 4.90/10，置信区间为 95%，效应量较大，这强烈支持 MSC 治疗缺血性中风的转化潜力。
