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[合成生物学在材料科学中的应用]

[Applications of synthetic biology in materials science].

作者信息

Zhao Tianxin, Zhong Chao

机构信息

School of Physical Science and Technology (SPST), Shanghai Tech University, Shanghai 201210, China.

出版信息

Sheng Wu Gong Cheng Xue Bao. 2017 Mar 25;33(3):494-505. doi: 10.13345/j.cjb.160399.

Abstract

Materials are the basis for human being survival and social development. To keep abreast with the increasing needs from all aspects of human society, there are huge needs in the development of advanced materials as well as high-efficiency but low-cost manufacturing strategies that are both sustainable and tunable. Synthetic biology, a new engineering principle taking gene regulation and engineering design as the core, greatly promotes the development of life sciences. This discipline has also contributed to the development of material sciences and will continuously bring new ideas to future new material design. In this paper, we review recent advances in applications of synthetic biology in material sciences, with the focus on how synthetic biology could enable synthesis of new polymeric biomaterials and inorganic materials, phage display and directed evolution of proteins relevant to materials development, living functional materials, engineered bacteria-regulated artificial photosynthesis system as well as applications of gene circuits for material sciences.

摘要

材料是人类生存和社会发展的基础。为了满足人类社会各方面不断增长的需求,先进材料的开发以及高效、低成本且可持续和可调节的制造策略存在巨大需求。合成生物学是以基因调控和工程设计为核心的新工程原理,极大地推动了生命科学的发展。该学科也为材料科学的发展做出了贡献,并将不断为未来的新材料设计带来新思想。在本文中,我们综述了合成生物学在材料科学中的应用进展,重点关注合成生物学如何实现新型高分子生物材料和无机材料的合成、与材料开发相关的蛋白质的噬菌体展示和定向进化、活性功能材料、工程细菌调控的人工光合作用系统以及基因回路在材料科学中的应用。

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