Randles Amanda, Frakes David H, Leopold Jane A
Duke University, Durham, NC, USA.
Arizona State University, Tempe, AZ, USA.
Trends Biotechnol. 2017 Nov;35(11):1049-1061. doi: 10.1016/j.tibtech.2017.08.008. Epub 2017 Sep 21.
Noninvasive engineering models are now being used for diagnosing and planning the treatment of cardiovascular disease. Techniques in computational modeling and additive manufacturing have matured concurrently, and results from simulations can inform and enable the design and optimization of therapeutic devices and treatment strategies. The emerging synergy between large-scale simulations and 3D printing is having a two-fold benefit: first, 3D printing can be used to validate the complex simulations, and second, the flow models can be used to improve treatment planning for cardiovascular disease. In this review, we summarize and discuss recent methods and findings for leveraging advances in both additive manufacturing and patient-specific computational modeling, with an emphasis on new directions in these fields and remaining open questions.
无创工程模型目前正用于心血管疾病的诊断和治疗规划。计算建模和增材制造技术同时成熟，模拟结果可为治疗设备和治疗策略的设计与优化提供信息并使其成为可能。大规模模拟与3D打印之间新出现的协同作用有双重好处：第一，3D打印可用于验证复杂的模拟；第二，流动模型可用于改进心血管疾病的治疗规划。在本综述中，我们总结并讨论了利用增材制造和患者特异性计算建模进展的最新方法和发现，重点关注这些领域的新方向和悬而未决的问题。
