Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD, 20993, USA.
, Silver Spring, USA.
J Cardiovasc Transl Res. 2018 Apr;11(2):80-88. doi: 10.1007/s12265-018-9792-2. Epub 2018 Mar 6.
Patient-specific computer models have been developed representing a variety of aspects of the cardiovascular system spanning the disciplines of electrophysiology, electromechanics, solid mechanics, and fluid dynamics. These physiological mechanistic models predict macroscopic phenomena such as electrical impulse propagation and contraction throughout the entire heart as well as flow and pressure dynamics occurring in the ventricular chambers, aorta, and coronary arteries during each heartbeat. Such models have been used to study a variety of clinical scenarios including aortic aneurysms, coronary stenosis, cardiac valvular disease, left ventricular assist devices, cardiac resynchronization therapy, ablation therapy, and risk stratification. After decades of research, these models are beginning to be incorporated into clinical practice directly via marketed devices and indirectly by improving our understanding of the underlying mechanisms of health and disease within a clinical context.
已经开发出了针对各种心血管系统方面的患者特异性计算机模型，涵盖了电生理学、机电学、固体力学和流体动力学等多个学科。这些生理机械模型预测了宏观现象，如整个心脏中的电脉冲传播和收缩，以及每个心跳期间心室腔、主动脉和冠状动脉中的流动和压力动力学。这些模型已被用于研究各种临床情况，包括主动脉瘤、冠状动脉狭窄、心脏瓣膜疾病、左心室辅助装置、心脏再同步治疗、消融治疗和风险分层。经过几十年的研究，这些模型开始通过市场上的设备直接纳入临床实践，或通过提高我们对临床环境中健康和疾病的潜在机制的理解间接纳入临床实践。
