Hitman G A, Karir P K, Sachs J A, Ramachandran A, Snehalatha C, Viswanathan M, Mohan V
Medical Unit, London Hospital Medical College, Whitechapel, UK.
Diabet Med. 1988 Jan;5(1):57-60. doi: 10.1111/j.1464-5491.1988.tb00942.x.
Recently close markers for insulin-dependent diabetes mellitus in Western 'Caucasoid' subjects have been defined from DQ region (both alpha and beta genes) restriction fragment length polymorphisms. In order to define the genetic contribution to insulin-dependent diabetes mellitus in an Indian population we have analysed 58 unrelated Dravidian (South Indian) insulin-dependent diabetic patients and 43 controls. In insulin-dependent diabetes an increased frequency of the Taq 1 DQ beta restriction fragment length polymorphisms designated T2 omega/T6 (relative risk = 10.6), and of homozygotes for Taq 1 DQ alpha 4.6 kb (relative risk = 11), was found in the patients. The highest relative risk for insulin-dependent diabetes mellitus was obtained by comparing patients and control subjects who either (a) co-inherited DQT2 omega/T6 with certain DQ alpha restriction fragment length polymorphisms or (b) were DQ alpha 4.6 kb homozygotes, the combination of (a) and (b) accounting for 55.5% of insulin-dependent diabetes mellitus subjects and none of the controls (relative risk = 101; 95% confidence limits 93-109).
最近，在西方“高加索人”中，已从DQ区域（α和β基因）限制性片段长度多态性中确定了胰岛素依赖型糖尿病的紧密标记。为了确定印度人群中胰岛素依赖型糖尿病的遗传因素，我们分析了58名不相关的达罗毗荼人（南印度人）胰岛素依赖型糖尿病患者和43名对照。在胰岛素依赖型糖尿病患者中，发现Taq 1 DQβ限制性片段长度多态性T2ω/T6（相对风险=10.6）以及Taq 1 DQα4.6 kb纯合子（相对风险=11）的频率增加。通过比较以下两种情况的患者和对照受试者，获得了胰岛素依赖型糖尿病的最高相对风险：（a）共同遗传DQ T2ω/T6与某些DQα限制性片段长度多态性，或（b）为DQα4.6 kb纯合子，（a）和（b）的组合占胰岛素依赖型糖尿病受试者的55.5%，而对照组中无一例（相对风险=101；95%置信区间93-109）。
