Zofková I, Zamrazil V
Research Institute of Endocrinology, Prague, Czechoslovakia.
Horm Metab Res. 1987 Dec;19(12):656-60. doi: 10.1055/s-2007-1011902.
A comparison is presented of the effect of two therapeutic doses of synthetic somatostatin (250 and 500 micrograms) and salmon calcitonin (50 and 100 U) on the blood levels of sugar, insulin (IRI), somatotropin (HGH) and cortisol in healthy volunteers following peroral administration of 75 g of glucose. Calcitonin was responsible for a significant change in glycaemia as well as IRI levels: following a retarded enhancement glycaemia as well as insulinaemia through out the first 15-30 minutes of OGTT, increased levels of both indicators were persistent at minute 120 and 180, so that the course of both curves was almost parallel. The effect was similar after SRIF had been administered, with the exception of insulin secretion being more pronounced, so that at a later stage of OGTT no hyperinsulinaemia was seen. The HGH levels tended to decrease due to both hormones, the tendency being more marked after SRIF, though statistically insignificant. There was a marked difference between the hormones as regards their effect on adrenocortical secretion. While the latter was constantly stimulated throughout OGTT under calcitonin infusion, the influence of SRIF was not significant. The metabolic and hormonal changes were found after both a lower and higher dose of both hormones, the only differences being that the inhibitory effect on the initial increase in glycaemia following a lower dose of SRIF was of no statistical significance. Hence, the metabolic and hormonal effects of calcitonin and SRIF in an acute experiment display many similarities, however, they do differ in some aspects; these effects do not depend on the doses demonstrated for both lower and higher doses of the above hormones.
本文比较了两种治疗剂量的合成生长抑素（250微克和500微克）和鲑鱼降钙素（50单位和100单位）对健康志愿者口服75克葡萄糖后血糖、胰岛素（IRI）、生长激素（HGH）和皮质醇血药浓度的影响。降钙素可导致血糖和IRI水平发生显著变化：在口服葡萄糖耐量试验（OGTT）的前15 - 30分钟，血糖和胰岛素血症的升高出现延迟，在第120分钟和180分钟时，这两个指标的水平持续升高，因此两条曲线的变化过程几乎平行。注射生长抑素后效果相似，只是胰岛素分泌更为明显，以至于在OGTT后期未出现高胰岛素血症。两种激素均可使HGH水平呈下降趋势，生长抑素作用后下降趋势更为明显，但差异无统计学意义。两种激素对肾上腺皮质分泌的影响存在显著差异。在降钙素输注的整个OGTT过程中，肾上腺皮质分泌持续受到刺激，而生长抑素的影响不显著。两种激素在较低剂量和较高剂量时均出现代谢和激素变化，唯一的差异是较低剂量生长抑素对血糖初始升高的抑制作用无统计学意义。因此，在急性实验中，降钙素和生长抑素的代谢和激素作用表现出许多相似之处，但在某些方面也存在差异；这些作用并不取决于上述激素较低剂量和较高剂量所显示的剂量。
